2. Gene
  3. DLGAP1 - DLG associated protein 1 Gene

DLGAP1 - DLG associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA

Gene ID: 9229 | Gene type: protein coding

About DLGAP1

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:3,496,032-4,455,307 (from NCBI)

This gene has 22 transcripts (splice variants), 286 orthologues and 4 paralogues. Biased expression in brain (RPKM 19.8), testis (RPKM 1.7) and 2 other tissues.

Summary

Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be part of postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP1 Products(29)

mRNA Protein Name
NM_001003809.3 NP_001003809.1 disks large-associated protein 1 isoform 2
NM_001242761.2 NP_001229690.1 disks large-associated protein 1 isoform 3
NM_001242762.2 NP_001229691.1 disks large-associated protein 1 isoform 4
NM_001242763.2 NP_001229692.1 disks large-associated protein 1 isoform 5
NM_001242764.2 NP_001229693.1 disks large-associated protein 1 isoform 6
NM_001242765.2 NP_001229694.1 disks large-associated protein 1 isoform 7
NM_001242766.2 NP_001229695.1 disks large-associated protein 1 isoform 8
NM_001308390.2 NP_001295319.1 disks large-associated protein 1 isoform 9
NM_001398525.1 NP_001385454.1 disks large-associated protein 1 isoform 10
NM_001398526.1 NP_001385455.1 disks large-associated protein 1 isoform 10
NM_001398527.1 NP_001385456.1 disks large-associated protein 1 isoform 1
NM_001398528.1 NP_001385457.1 disks large-associated protein 1 isoform 11
NM_001398530.1 NP_001385459.1 disks large-associated protein 1 isoform 12
NM_001398531.1 NP_001385460.1 disks large-associated protein 1 isoform 13
NM_001398532.1 NP_001385461.1 disks large-associated protein 1 isoform 14
NM_001398533.1 NP_001385462.1 disks large-associated protein 1 isoform 15
NM_001398534.1 NP_001385463.1 disks large-associated protein 1 isoform 16
NM_001398535.1 NP_001385464.1 disks large-associated protein 1 isoform 17
NM_001398536.1 NP_001385465.1 disks large-associated protein 1 isoform 18
NM_001398537.1 NP_001385466.1 disks large-associated protein 1 isoform 19
NM_001398539.1 NP_001385468.1 disks large-associated protein 1 isoform 20
NM_001398540.1 NP_001385469.1 disks large-associated protein 1 isoform 21
NM_001398541.1 NP_001385470.1 disks large-associated protein 1 isoform 22
NM_001398542.1 NP_001385471.1 disks large-associated protein 1 isoform 23
NM_001398543.1 NP_001385472.1 disks large-associated protein 1 isoform 24
NM_001398544.1 NP_001385473.1 disks large-associated protein 1 isoform 25
NM_001398545.1 NP_001385474.1 disks large-associated protein 1 isoform 26
NM_001398546.1 NP_001385475.1 disks large-associated protein 1 isoform 27
NM_004746.4 NP_004737.2 disks large-associated protein 1 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLGAP1 Protein Structure

GKAP

GKAP: Guanylate-kinase-associated protein (GKAP) protein (640 - 977)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

disks large-associated protein 1

PSD-95/SAP90 binding protein 1

Related Diseases

Diseases Alias
Retinitis Pigmentosa 55

RP55

Retinitis Pigmentosa, Type 55
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior
Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder
Transient Tic Disorder
Childhood Acute Megakaryoblastic Leukemia

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome

22q13.3 Deletion Syndrome

Telomeric 22q13 Monosomy Syndrome

PHMDS

Deletion 22q13 Syndrome

22q13.3 Deletion

Deletion 22q13.3 Syndrome

Monosomy 22q13

Monosomy 22q13.3

22q13 Deletion Syndrome

Monosomy 22q13 Syndrome

22q13 Deletion

Chromosome Deletion
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Body Dysmorphic Disorder

Dysmorphophobia

Body Dysmorphia

Dysmorphic Syndrome

Body Dysmorphic Disorders
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03801 DLGAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DLGAP1 MGD MGI:1346065
Canis familiaris DLGAP1 VGNC VGNC:39979
Rattus norvegicus DLGAP1 RGD RGD:620223
Bos taurus DLGAP1 VGNC VGNC:28088
Felis catus DLGAP1 VGNC VGNC:80437
Macaca mulatta DLGAP1 VGNC VGNC:97759