2. Gene
  3. RAB11B - RAB11B, member RAS oncogene family Gene

RAB11B - RAB11B, member RAS oncogene family Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H-YPT3; NDAGSCW

Gene ID: 9230 | Gene type: protein coding

About RAB11B

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,390,360-8,404,434 (from NCBI)

This gene has 5 transcripts (splice variants), 115 orthologues, 68 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 36.5), thyroid (RPKM 36.2) and 25 other tissues.

Summary

The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

RAB11B Products(1)

mRNA Protein Name
NM_004218.4 NP_004209.2 ras-related protein Rab-11B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GDP binding IDA
IDA: Inferred from direct assay
16545962 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
16545962 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
16545962 GOA
enables myosin V binding IPI
IPI: Inferred from physical interaction
24006491 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20717956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance by transcytosis IGI
IGI: Inferred from genetic interaction
26005850 GOA
involved in cellular response to acidic pH IDA
IDA: Inferred from direct assay
20717956 GOA
involved in constitutive secretory pathway IMP
IMP: Inferred from mutant phenotype
14627637 GOA
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
19244346 GOA
involved in establishment of protein localization to membrane IMP
IMP: Inferred from mutant phenotype
24006491 GOA
involved in regulation of monoatomic anion transport IMP
IMP: Inferred from mutant phenotype
19244346 GOA
involved in regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
20717956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
21255211 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB11B Protein Structure

Ras

Ras: Ras family (13 - 173)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-11B

GTP-binding protein YPT3

RAB11B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RAB11B Q15907 RAB11FIP2 Homo sapiens Q7L804
Anti Tag CoIP
28514442
Intra
RAB11B Q15907 RAB11FIP2 Homo sapiens Q7L804
Anti Tag CoIP
33961781
Intra
RAB11B Q15907 RAB11FIP2 Homo sapiens Q7L804
Validated Y2H
32296183
Intra
RAB11B Q15907 RAB11FIP2 Homo sapiens Q7L804
Anti Tag CoIP
35271311
Intra
RAB11B Q15907 MYO5B Homo sapiens Q9ULV0-2
Validated Y2H
32296183
Intra
RAB11B Q15907 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
RAB11B Q15907 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RAB11B Q15907 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RAB11B Q15907 TBC1D14 Homo sapiens Q9P2M4
Anti Tag CoIP
22613832
Intra
RAB11B Q15907 TBC1D14 Homo sapiens Q9P2M4
Y2H
22613832
Intra
RAB11B Q15907 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
RAB11B Q15907 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
RAB11B Q15907 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
RAB11B Q15907 SH3BP5L Homo sapiens Q7L8J4
Anti Tag CoIP
33961781
Intra
RAB11B Q15907 SH3BP5L Homo sapiens Q7L8J4
Y2H Array
32296183
Intra
RAB11B Q15907 SH3BP5L Homo sapiens Q7L8J4
Y2H Prey Pooling
32296183
Intra
RAB11B Q15907 SH3BP5L Homo sapiens Q7L8J4
Anti Tag CoIP
28514442
Intra
RAB11B Q15907 SH3BP5L Homo sapiens Q7L8J4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB11B Proteins

Cat. No. Product Name Accession Purity
HY-P74610 RAB11B Protein, Human (HEK293, His) Q15907-1 (G2-C215) ≥95%

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter

NDAGSCW

Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, Decreased Cortical White Matter
Esophagus Sarcoma

Esophageal Sarcoma
Hypotrichosis 3

HYPT3

Hypotrichosis Simplex Of The Scalp 2

Htss2

Hypotrichosis, Type 3
Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum
Rectal Benign Neoplasm

Neoplasm Of Rectum

Rectal Tumor

Rectum Neoplasm

Neoplasm Of The Rectum

Rectal Neoplasms

Primary Rectal Cancer

Rectal Ampulla Cancer

Cancer Of The Rectum

Carcinoma Of Rectum

Primary Malignant Neoplasm Of Rectum

Rectal Cancer

Rectal Carcinoma
Rectum Cancer

Malignant Neoplasm Of Rectum

Rectal Cancer

Cancer Of Rectum

Carcinoma Of Rectum

Carcinoma Of The Rectum

Malignant Rectal Tumor

Malignant Rectum Tumor

Malignant Tumor Of Rectum

Rectal Carcinoma

Rectal Cancers

Cancer, Rectal
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11516 RAB11B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAB11B VGNC VGNC:81518
Mus musculus RAB11B MGD MGI:99425
Felis catus RAB11B VGNC VGNC:97580
Canis familiaris RAB11B VGNC VGNC:45249
Rattus norvegicus RAB11B RGD RGD:68369
Bos taurus RAB11B VGNC VGNC:33615
Others RAB11B NCBI