CRLF1 - cytokine receptor like factor 1 Gene

Homo sapiens

Also known as CLF; NR6; CISS; CISS1; CLF-1; zcytor5

Gene ID: 9244 | Gene type: protein coding

About CRLF1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,593,237-18,606,799 (from NCBI)

This gene has 6 transcripts (splice variants), 173 orthologues, 23 paralogues and is associated with 5 phenotypes. Broad expression in placenta (RPKM 4.8), brain (RPKM 3.2) and 15 other tissues.

Summary

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]

CRLF1 Products(1)

mRNA	Protein	Name
NM_004750.5	NP_004741.1	cytokine receptor-like factor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to ciliary neurotrophic factor receptor binding	IDA IDA: Inferred from direct assay	10966616	GOA
contributes to cytokine activity	IDA IDA: Inferred from direct assay	10966616	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	15034937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10966616	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	10966616	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	10966616	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10966616	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CRLF-CLCF1 complex	IDA IDA: Inferred from direct assay	10966616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRLF1 Protein Structure

EpoR_lig-bind

fn3

0
100
200
300
422 a.a.

Protein Preferred Names

Protein Names

cytokine receptor-like factor 1

class I cytokine receptor

CRLF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRLF1	O75462	SORL1	Homo sapiens	Q92673	SPR	26858303

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Crisponi/Cold-Induced Sweating Syndrome 1

Crisponi Syndrome	Cold-Induced Sweating Syndrome 1
CISS1	Sohar-Crisponi Syndrome
Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death	Muscle Contractions Tetanoform With Characteristic Face Camptodactyly Hyperthermia And Sudden Death

Cold-Induced Sweating Syndrome

Crisponi Syndrome	Sohar-Crisponi Syndrome
Ciss	Cntf Receptor-Related Disorders
Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death	Sweating Syndrome, Cold-Induced

Cold-Induced Sweating Syndrome Including Crisponi Syndrome

Crisponi/Cold-Induced Sweating Syndrome

Achalasia

Cardiospasm	Achalasia Of Cardia
Esophageal Achalasia	Hypertensive Lower Esophageal Sphincter
Idiopathic Achalasia	Achalasia Cardia
Idiopathic Achalasia Of Esophagus	Primary Achalasia
Achalasia Of Esophagus	Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter
Aperistalsis Of The Oesophagus	Achalasia Of Oesophagus
Oesophageal Achalasia	Achalasia Nos
Cardia Spasm	Cardia Achalasia
Oesophageal Cardiospasm	Oesophagus Achalasia
Reflex Cardiospasm

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2	CISS2
Sweating Syndrome, Cold-Induced, Type 2

Retinitis Pigmentosa 42

RP42	Retinitis Pigmentosa-42
Retinitis Pigmentosa, Type 42

Developmental And Epileptic Encephalopathy 11

Epileptic Encephalopathy, Early Infantile, 11	DEE11
Eiee11	Developmental And Epileptic Encephalopathy, 11
Early Infantile Epileptic Encephalopathy 11	Encephalopathy, Developmental And Epileptic, Type 11

Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay

CLIFAHDD	Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome
Clifahdd Syndrome	Doid:0081048
Contractures, Limbs And Face, Congenital, Hypotonia, And Developmental Delay

Tetanus Neonatorum

Neonatal Tetanus	NNT
Trismus Neonatorum	Newborn Trismus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03186	CRLF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CRLF1	VGNC	VGNC:109610
Canis familiaris	CRLF1	VGNC	VGNC:39620
Felis catus	CRLF1	VGNC	VGNC:61183
Rattus norvegicus	CRLF1	RGD	RGD:1311371
Bos taurus	CRLF1	VGNC	VGNC:27717
Mus musculus	CRLF1	MGD	MGI:1340030
Others	CRLF1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.