FANK1 - fibronectin type III and ankyrin repeat domains 1 Gene

Homo sapiens

Also known as HSD13

Gene ID: 92565 | Gene type: protein coding

About FANK1

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,896,564-126,009,592 (from NCBI)

This gene has 10 transcripts (splice variants) and 147 orthologues. Biased expression in testis (RPKM 5.5), thyroid (RPKM 1.2) and 10 other tissues.

Summary

Involved in regulation of apoptotic process and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]

FANK1 Products(3)

mRNA	Protein	Name
NM_001350939.2	NP_001337868.1	fibronectin type 3 and ankyrin repeat domains protein 1 isoform 1
NM_001363549.2	NP_001350478.1	fibronectin type 3 and ankyrin repeat domains protein 1 isoform 3
NM_145235.5	NP_660278.3	fibronectin type 3 and ankyrin repeat domains protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20978819	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20978819	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20978819	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27060496	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	27060496	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20978819	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	27060496	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20978819	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20978819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FANK1 Protein Structure

Ank_2

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

fibronectin type 3 and ankyrin repeat domains protein 1

fibronectin type 3 and ankyrin repeat domains 1

FANK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FANK1	Q8TC84	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	FANK1	Q8TC84	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	FANK1	Q8TC84	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	FANK1	Q8TC84	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	FANK1	Q8TC84	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	FANK1	Q8TC84	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	FANK1	Q8TC84	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	FANK1	Q8TC84	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	FANK1	Q8TC84	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	FANK1	Q8TC84	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	FANK1	Q8TC84	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	FANK1	Q8TC84	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	FANK1	Q8TC84	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	FANK1	Q8TC84	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FANK1	Q8TC84	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nodular Nonsuppurative Panniculitis

Weber-Christian Disease	Relapsing Febrile Nodular Nonsuppurative Panniculitis
Idiopathic Nodular Panniculitis	Pfeiffer-Weber-Christian Syndrome
Weber-Christian Panniculitis	Panniculitis, Nodular Nonsuppurative
Nodular Non-Suppurative Febrile Panniculitis	Weber - Christian Disease
Panniculitis Nodular Nonsuppurative	Nodular Non-Suppurative Panniculitis
Idiopathic Lobular Panniculitis	Relapsing Febrile Nodular Panniculitis
Wcd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04742	FANK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FANK1	VGNC	VGNC:40726
Bos taurus	FANK1	VGNC	VGNC:28861
Macaca mulatta	FANK1	VGNC	VGNC:72559
Mus musculus	FANK1	MGD	MGI:1914180
Felis catus	FANK1	VGNC	VGNC:62145
Rattus norvegicus	FANK1	RGD	RGD:1304756

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