OTOP2 - otopetrin 2 Gene

Homo sapiens

Gene ID: 92736 | Gene type: protein coding

About OTOP2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,924,273-74,933,912 (from NCBI)

This gene has 3 transcripts (splice variants), 247 orthologues and 2 paralogues. Biased expression in colon (RPKM 10.3), testis (RPKM 1.8) and 1 other tissue.

Summary

Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

OTOP2 Products(1)

mRNA	Protein	Name
NM_178160.3	NP_835454.1	proton channel OTOP2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTOP2 Protein Structure

Otopetrin

0
100
200
300
400
500
562 a.a.

Protein Preferred Names

Protein Names

proton channel OTOP2

OTOP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OTOP2	Q7RTS6	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	OTOP2	Q7RTS6	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	OTOP2	Q7RTS6	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	OTOP2	Q7RTS6	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	OTOP2	Q7RTS6	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	OTOP2	Q7RTS6	MANBAL	Homo sapiens	Q9NQG1	Y2H Prey Pooling	32296183
Intra	OTOP2	Q7RTS6	MANBAL	Homo sapiens	Q9NQG1	Validated Y2H	32296183
Intra	OTOP2	Q7RTS6	MANBAL	Homo sapiens	Q9NQG1	Y2H Array	32296183
Intra	OTOP2	Q7RTS6	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	OTOP2	Q7RTS6	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	OTOP2	Q7RTS6	FATE1	Homo sapiens	Q969F0	Complementation	32296183
Intra	OTOP2	Q7RTS6	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	OTOP2	Q7RTS6	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	OTOP2	Q7RTS6	CD79A	Homo sapiens	P11912	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Vertigo, Benign Recurrent

Benign Paroxysmal Positional Vertigo	Bppv
Vestibulopathy, Familial	BRV
Vertigo, Benign Paroxysmal Positional	Benign Paroxysmal Positional Nystagmus
Benign Recurrent Vertigo	Familial Benign Recurrent Vertigo
Familial Vestibulopathy	Benign Paroxysmal Nystagmus
Bppv - [Benign Positional Paroxysmal Vertigo]

Diversion Colitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09865	OTOP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OTOP2	VGNC	VGNC:63996
Macaca mulatta	OTOP2	VGNC	VGNC:104639
Mus musculus	OTOP2	MGD	MGI:2388365
Bos taurus	OTOP2	VGNC	VGNC:32489
Rattus norvegicus	OTOP2	RGD	RGD:1304830

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