ORAI3 - ORAI calcium release-activated calcium modulator 3 Gene

Homo sapiens

Also known as TMEM142C

Gene ID: 93129 | Gene type: protein coding

About ORAI3

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,949,068-30,954,938 (from NCBI)

This gene has 4 transcripts (splice variants), 99 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues.

Summary

Predicted to enable store-operated Calcium Channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ORAI3 Products(1)

mRNA	Protein	Name
NM_152288.3	NP_689501.1	protein orai-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17442569	GOA
enables store-operated calcium channel activity	IDA IDA: Inferred from direct assay	17442569	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in store-operated calcium entry	IDA IDA: Inferred from direct assay	19182790	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	32415068	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORAI3 Protein Structure

Orai-1

0
100
200
295 a.a.

Protein Preferred Names

Protein Names

protein orai-3

transmembrane protein 142C

ORAI3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ORAI3	Q9BRQ5	ORAI1	Homo sapiens	Q96D31	Anti Bait CoIP	24954132

Cross: Cross-species interaction Intra: Intraspecies interaction

ORAI3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83383	ORAI3 Antibody (YA3128)	WB, IHC-P	Human

Related Diseases

Diseases

Alias

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Estrogen-Receptor Positive Breast Cancer

Estrogen-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103071	GSK-5503A	Inhibitor	/	Unkown
HY-RS09824	ORAI3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ORAI3	MGD	MGI:3039586
Rattus norvegicus	ORAI3	RGD	RGD:1306538
Macaca mulatta	ORAI3	VGNC	VGNC:75688
Bos taurus	ORAI3	VGNC	VGNC:32445
Canis familiaris	ORAI3	VGNC	VGNC:44139
Felis catus	ORAI3	VGNC	VGNC:107767

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