ORAI1 - ORAI calcium release-activated calcium modulator 1 Gene

Homo sapiens

Also known as IMD9; TAM2; ORAT1; CRACM1; TMEM142A

Gene ID: 84876 | Gene type: protein coding

About ORAI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,626,550-121,642,040 (from NCBI)

Summary

The protein encoded by this gene is a membrane Calcium Channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

ORAI1 Products(1)

mRNA	Protein	Name
NM_032790.3	NP_116179.2	calcium release-activated calcium channel protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	31009446	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18757751	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17360584	GOA
enables store-operated calcium channel activity	IDA IDA: Inferred from direct assay	16645049	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	33941685	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	31009446	GOA
involved in positive regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	19171672	GOA
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	16645049	GOA
involved in regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	16921383	GOA
involved in store-operated calcium entry	IDA IDA: Inferred from direct assay	16921383	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane raft	IDA IDA: Inferred from direct assay	22494970	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16645049	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	19171672	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORAI1 Protein Structure

Orai-1

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

calcium release-activated calcium channel protein 1

calcium release-activated calcium modulator 1

ORAI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	ORAI1	Q96D31	Trpc6	Mus musculus	Q61143	Anti Tag CoIP	17360584
Cross	ORAI1	Q96D31	Trpc6	Mus musculus	Q61143	Pull Down	17360584
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Pull Down	19249086
Intra	ORAI1	Q96D31	ORAI1	Homo sapiens	Q96D31	Crosslink	20018736
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Ub Reconstruction	19249086
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	19249086
Intra	ORAI1	Q96D31	ORAI1	Homo sapiens	Q96D31	GMS	19249086
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	19706554
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	AFM	24996186
Intra	ORAI1	Q96D31	ORAI1	Homo sapiens	Q96D31	FRET	18757751
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	GMS	19249086
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	20418871
Intra	ORAI1	Q96D31	EFHB	Homo sapiens	Q8N7U6	Anti Bait CoIP	30481768
Intra	ORAI1	Q96D31	ATP2C2	Homo sapiens	O75185	Confocal	20887894
Intra	ORAI1	Q96D31	ATP2C2	Homo sapiens	O75185	Anti Bait CoIP	20887894
Intra	ORAI1	Q96D31	ATP2C2	Homo sapiens	O75185	Pull Down	20887894
Intra	ORAI1	Q96D31	ORAI3	Homo sapiens	Q9BRQ5	Confocal	24954132
Intra	ORAI1	Q96D31	ORAI3	Homo sapiens	Q9BRQ5	FRET	19887627
Intra	ORAI1	Q96D31	CRACR2A	Homo sapiens	Q9BSW2	Anti Tag CoIP	20418871
Intra	ORAI1	Q96D31	CRACR2A	Homo sapiens	Q9BSW2	Pull Down	20418871
Intra	ORAI1	Q96D31	TRPC1	Homo sapiens	P48995	Anti Bait CoIP	21408196

Cross: Cross-species interaction Intra: Intraspecies interaction

ORAI1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83412	ORAI1 Antibody (YA3157)	WB	Human

Related Diseases

Diseases

Alias

Immunodeficiency 9

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1	Combined Immunodeficiency Due To Orai1 Deficiency
IMD9	Cid Due To Orai1 Deficiency
Severe Combined Immunodeficiency Due To Crac Channel Dysfunction	Immunodeficiency, Type 9

Myopathy, Tubular Aggregate, 2

TAM2	Tubular Aggregate Myopathy 2

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Anhidrosis

Hypohidrosis	Absence Of Sweating
Adiaphoresis	Impaired Sweating
Oligohidrosis

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Urolithiasis

Myopathy

Muscular Diseases

Myopathies

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101942	Zegocractin	Inhibitor	99.96%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19408	Pyr10	Inhibitor	99.42%	Unkown
HY-103310	MRS1845	Inhibitor	99.69%	Unkown
HY-113618B	RO2959 monohydrochloride	Inhibitor	98.21%	Unkown
HY-12521	GSK-5498A	Inhibitor	97.45%	Unkown
HY-113618A	RO2959 hydrochloride	Inhibitor	/	Unkown
HY-103071	GSK-5503A	Inhibitor	/	Unkown
HY-RS09822	ORAI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990478	Anti-Orai1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ORAI1	VGNC	VGNC:44137
Rattus norvegicus	ORAI1	RGD	RGD:1311873
Mus musculus	ORAI1	MGD	MGI:1925542
Bos taurus	ORAI1	VGNC	VGNC:32443
Macaca mulatta	ORAI1	VGNC	VGNC:75464
Felis catus	ORAI1	VGNC	VGNC:63971

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