PRDM6 - PR/SET domain 6 Gene

Homo sapiens

Also known as PDA3; KMT8C; PRISM

Gene ID: 93166 | Gene type: protein coding

About PRDM6

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:123,089,241-123,194,266 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 36 paralogues and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 2.3), placenta (RPKM 2.0) and 16 other tissues.

Summary

The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]

PRDM6 Products(1)

mRNA	Protein	Name
NM_001136239.4	NP_001129711.1	putative histone-lysine N-methyltransferase PRDM6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16537907	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM6 Protein Structure

SET

zf-C2H2_4

zf-C2H2

zf-H2C2_2

0
100
200
300
400
500
595 a.a.

Protein Preferred Names

Protein Names

putative histone-lysine N-methyltransferase PRDM6

PR domain 6

PRDM6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRDM6	Q9NQX0	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PRDM6	Q9NQX0	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PRDM6	Q9NQX0	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PRDM6	Q9NQX0	FOXD4L1	Homo sapiens	Q9NU39	Validated Y2H	32296183
Intra	PRDM6	Q9NQX0	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	PRDM6	Q9NQX0	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	PRDM6	Q9NQX0	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	PRDM6	Q9NQX0	SAMD4A	Homo sapiens	Q9UPU9-3	Validated Y2H	32296183
Intra	PRDM6	Q9NQX0	IL16	Homo sapiens	Q14005-2	Y2H Array	32296183
Intra	PRDM6	Q9NQX0	FTO	Homo sapiens	Q9C0B1-2	Y2H Array	32296183
Intra	PRDM6	Q9NQX0	FTO	Homo sapiens	Q9C0B1-2	Y2H Prey Pooling	32296183
Intra	PRDM6	Q9NQX0	AHCYL1	Homo sapiens	O43865	Y2H Array	32296183
Intra	PRDM6	Q9NQX0	AHCYL1	Homo sapiens	O43865	Y2H Prey Pooling	32296183
Intra	PRDM6	Q9NQX0	CCNL1	Homo sapiens	Q9UK58	Validated Y2H	32296183
Intra	PRDM6	Q9NQX0	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	PRDM6	Q9NQX0	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	PRDM6	Q9NQX0	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Patent Ductus Arteriosus 3

PDA3

Familial Patent Arterial Duct

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11070	PRDM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRDM6	VGNC	VGNC:44950
Rattus norvegicus	PRDM6	RGD	RGD:1559594
Felis catus	PRDM6	VGNC	VGNC:69036
Mus musculus	PRDM6	MGD	MGI:2684938
Bos taurus	PRDM6	VGNC	VGNC:33298
Macaca mulatta	PRDM6	VGNC	VGNC:110444

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