1. Gene
  2. AHCYL1 - adenosylhomocysteinase like 1 Gene

AHCYL1 - adenosylhomocysteinase like 1 Gene

Homo sapiens

Also known as DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA

Gene ID: 10768 | Gene type: protein coding

About AHCYL1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,984,765-110,023,742 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 81.1), duodenum (RPKM 50.1) and 25 other tissues.

Summary

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AHCYL1 Products(5)

mRNA Protein Name
NM_001242673.2 NP_001229602.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242674.2 NP_001229603.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242675.2 NP_001229604.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242676.2 NP_001229605.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_006621.7 NP_006612.2 S-adenosylhomocysteine hydrolase-like protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16769890 GOA
Biological Process GO Annotation Evidence Reference Source
involved in angiotensin-activated signaling pathway IDA
IDA: Inferred from direct assay
20584908 GOA
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
27995898 GOA
involved in mitochondrion-endoplasmic reticulum membrane tethering IMP
IMP: Inferred from mutant phenotype
27995898 GOA
involved in positive regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
16769890 GOA
involved in regulation of mRNA 3'-end processing IDA
IDA: Inferred from direct assay
19224921 GOA
involved in regulation of monoatomic ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
16769890 GOA
involved in response to calcium ion IDA
IDA: Inferred from direct assay
18829453 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
27995898 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHCYL1 Protein Structure

AdoHcyase

AdoHcyase: S-adenosyl-L-homocysteine hydrolase (104 - 529)

AdoHcyase_NAD

AdoHcyase_NAD: S-adenosyl-L-homocysteine hydrolase, NAD binding domain (289 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
Protein Preferred Names Protein Names

S-adenosylhomocysteine hydrolase-like protein 1

DC-expressed AHCY-like molecule

AHCYL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AHCYL1 O43865 ZNF165 Homo sapiens Q53Z40 25416956
Intra
AHCYL1 O43865 ZNF165 Homo sapiens Q53Z40 25416956
Intra
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2 25416956
Intra
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2 32296183
Intra
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2 32296183
Intra
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2 25416956
Intra
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2 32296183
Intra
AHCYL1 O43865 HBQ1 Homo sapiens P09105 32296183
Intra
AHCYL1 O43865 HBQ1 Homo sapiens P09105 32296183
Intra
AHCYL1 O43865 HBQ1 Homo sapiens P09105 32296183
Intra
AHCYL1 O43865 HBQ1 Homo sapiens P09105 32296183
Intra
AHCYL1 O43865 BID Homo sapiens P55957-2 25416956
Intra
AHCYL1 O43865 BID Homo sapiens P55957-2 25416956
Intra
AHCYL1 O43865 PRDM6 Homo sapiens Q9NQX0 32296183
Intra
AHCYL1 O43865 PLEKHG5 Homo sapiens O94827-4 32296183
Intra
AHCYL1 O43865 SLC23A1 Homo sapiens Q9UHI7-3 32296183
Intra
AHCYL1 O43865 JOSD2 Homo sapiens Q8TAC2 32296183
Intra
AHCYL1 O43865 JOSD2 Homo sapiens Q8TAC2 32296183
Intra
AHCYL1 O43865 JOSD2 Homo sapiens Q8TAC2 32296183
Intra
AHCYL1 O43865 SLC23A1 Homo sapiens Q9UHI7 25416956
Intra
AHCYL1 O43865 BCL2L10 Homo sapiens Q9HD36 27995898
Intra
AHCYL1 O43865 BCL2L10 Homo sapiens Q9HD36 27995898
Intra
AHCYL1 O43865 HEXIM2 Homo sapiens Q96MH2 32296183
Intra
AHCYL1 O43865 CDKN2C Homo sapiens P42773 31515488
Intra
AHCYL1 O43865 CDKN2C Homo sapiens P42773 25416956
Intra
AHCYL1 O43865 CDKN2C Homo sapiens P42773 25416956
Intra
AHCYL1 O43865 CDKN2C Homo sapiens P42773 32296183
Intra
AHCYL1 O43865 UACA Homo sapiens Q9BZF9 32296183
Intra
AHCYL1 O43865 HSPA6 Homo sapiens P17066 32296183
Intra
AHCYL1 O43865 HSPA6 Homo sapiens P17066 32296183
Intra
AHCYL1 O43865 HSPA6 Homo sapiens P17066 32296183
Intra
AHCYL1 O43865 PPL Homo sapiens O60437 25416956
Intra
AHCYL1 O43865 PPL Homo sapiens O60437 25416956
Intra
AHCYL1 O43865 BID Homo sapiens P55957 25416956
Intra
AHCYL1 O43865 BID Homo sapiens P55957 25416956
Intra
AHCYL1 O43865 BID Homo sapiens P55957 25416956
Intra
AHCYL1 O43865 LRRK2 Homo sapiens Q5S007 29513927
Intra
AHCYL1 O43865 MAGEA2 Homo sapiens P43356 32814053
Intra
AHCYL1 O43865 MAGEA2 Homo sapiens P43356 32814053
Intra
AHCYL1 O43865 MAGEA2 Homo sapiens P43356 32814053
Intra
AHCYL1 O43865 ZNF165 Homo sapiens P49910 32296183
Intra
AHCYL1 O43865 ZNF165 Homo sapiens P49910 32296183
Intra
AHCYL1 O43865 ZNF165 Homo sapiens P49910 32296183
Intra
AHCYL1 O43865 SOX30 Homo sapiens O94993 25416956
Intra
AHCYL1 O43865 GEM Homo sapiens P55040 32296183
Intra
AHCYL1 O43865 GEM Homo sapiens P55040 25416956
Intra
AHCYL1 O43865 MEOX2 Homo sapiens P50222 25416956
Intra
AHCYL1 O43865 MEOX2 Homo sapiens P50222 25416956
Intra
AHCYL1 O43865 PSMD9 Homo sapiens O00233 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intestinal Impaction
Spinocerebellar Ataxia 29

Spinocerebellar Ataxia Type 29

SCA29

Cnpca

Cerebellar Vermis Aplasia

Aplasia Of Cerebellar Vermis

Acv

Cerebellar Ataxia, Congenital Nonprogressive, Autosomal Dominant

Spinocerebellar Ataxia 29, Congenital Nonprogressive

Congenital Nonprogressive Spinocerebellar Ataxia

Autosomal Dominant Congenital Nonprogressive Cerebellar Ataxia

Ataxia, Spinocerebellar, Type 29, Congenital Nonprogressive

Familial Aplasia Of The Vermis

Cerebral Palsy, Ataxic, Autosomal Recessive

Ataxic Cerebral Palsy

Acp

Hypotonic Cerebral Palsy

Cerebral Palsy Ataxic

Cerebral Palsy, Atonic

Congenital Cerebral Palsy With Ataxia

Ataxic Cerebral Paralysis

Ataxia With Cerebral Palsy

Cerebral Infantile Diataxia

Spinocerebellar Ataxia, Autosomal Recessive 13

Autosomal Recessive Spinocerebellar Ataxia 13

SCAR13

Autosomal Recessive Congenital Cerebellar Ataxia Due To Mglur1 Deficiency

Autosomal Recessive Congenital Cerebellar Ataxia Due To Metabotropic Glutamate Receptor 1 Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 13

Spinocerebellar Ataxia, Autosomal Recessive, 13

Ataxia, Spinocerebellar, Autosomal Recessive, Type 13

Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6

Kallmann Syndrome 6

Kal6

Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia

Gillespie Syndrome

GLSP

Aniridia, Cerebellar Ataxia And Mental Deficiency

Aniridia Cerebellar Ataxia Mental Deficiency

Aniridia, Cerebellar Ataxia, And Mental Retardation

Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome

Aniridia-Cerebellar Ataxia-Intellectual Disability

Aniridia-Cerebellar Ataxia-Mental Deficiency

Partial Aniridia-Cerebellar Ataxia-Oligophrenia

Aniridia, Cerebellar Ataxia, And Intellectual Disability

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris AHCYL1 VGNC VGNC:37725
Felis catus AHCYL1 VGNC VGNC:80130
Rattus norvegicus AHCYL1 RGD RGD:1309768
Mus musculus AHCYL1 MGD MGI:2385184
Macaca mulatta AHCYL1 VGNC VGNC:81350
Bos taurus AHCYL1 VGNC VGNC:25751