2. Gene
  3. TAOK2 - TAO kinase 2 Gene

TAOK2 - TAO kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PSK; PSK1; TAO1; TAO2; MAP3K17; Tao2beta; PSK1-BETA

Gene ID: 9344 | Gene type: protein coding

About TAOK2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,973,868-29,992,261 (from NCBI)

This gene has 6 transcripts (splice variants), 148 orthologues and 35 paralogues. Ubiquitous expression in fat (RPKM 12.5), testis (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

TAOK2 Products(3)

mRNA Protein Name
NM_001252043.2 NP_001238972.1 serine/threonine-protein kinase TAO2 isoform 3
NM_004783.4 NP_004774.1 serine/threonine-protein kinase TAO2 isoform 2
NM_016151.4 NP_057235.2 serine/threonine-protein kinase TAO2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mitogen-activated protein kinase kinase binding IPI
IPI: Inferred from physical interaction
11279118 GOA
enables neuropilin binding IPI
IPI: Inferred from physical interaction
22683681 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10660600 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
17396146 GOA
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
10660600 GOA
involved in axonogenesis IGI
IGI: Inferred from genetic interaction
22683681 GOA
involved in focal adhesion assembly IDA
IDA: Inferred from direct assay
10660600 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17396146 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
10660600 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
10660600 GOA
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
17396146 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
10660600 GOA
involved in stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
11279118 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
10660600 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAOK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (30 - 281)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1235 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase TAO2

PSK-1

TAOK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TAOK2 Q9UL54 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
TAOK2 Q9UL54 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
TAOK2 Q9UL54 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
TAOK2 Q9UL54 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
TAOK2 Q9UL54 MAPRE3 Homo sapiens Q9UPY8
Y2H Prey Pooling
32296183
Intra
TAOK2 Q9UL54 MAPRE3 Homo sapiens Q9UPY8
Y2H Array
32296183
Intra
TAOK2 Q9UL54 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TAOK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82915 Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) WB, IHC-P Human, Mouse, Rat

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-100491 H3B-6527 Inhibitor ≥98.0% Phase 1
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15141 Staurosporine 99.98% Unkown
HY-122232 SW083688 Inhibitor / Unkown
HY-RS14199 TAOK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TAOK2 MGD MGI:1915919
Rattus norvegicus TAOK2 RGD RGD:621590
Felis catus TAOK2 VGNC VGNC:107821
Bos taurus TAOK2 VGNC VGNC:35596
Macaca mulatta TAOK2 VGNC VGNC:81592
Canis familiaris TAOK2 VGNC VGNC:47103
Others TAOK2 NCBI