TRMT10A - tRNA methyltransferase 10A Gene

Homo sapiens

Also known as MSSGM; TRM10; MSSGM1; RG9MTD2; HEL-S-88

Gene ID: 93587 | Gene type: protein coding

About TRMT10A

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,546,711-99,564,039 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 4.1), thyroid (RPKM 2.7) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

TRMT10A Products(6)

mRNA	Protein	Name
NM_001134665.3	NP_001128137.1	tRNA methyltransferase 10 homolog A isoform 1
NM_001134666.3	NP_001128138.1	tRNA methyltransferase 10 homolog A isoform 1
NM_001375880.1	NP_001362809.1	tRNA methyltransferase 10 homolog A isoform 1
NM_001375881.1	NP_001362810.1	tRNA methyltransferase 10 homolog A isoform 1
NM_001375882.1	NP_001362811.1	tRNA methyltransferase 10 homolog A isoform 2
NM_152292.5	NP_689505.1	tRNA methyltransferase 10 homolog A isoform 1

TRMT10A Protein Structure

tRNA_m1G_MT

0
100
200
300
339 a.a.

Protein Preferred Names

Protein Names

tRNA methyltransferase 10 homolog A

RNA (guanine-9-)-methyltransferase domain-containing protein 2

TRMT10A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRMT10A	Q8TBZ6	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
Intra	TRMT10A	Q8TBZ6	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
Intra	TRMT10A	Q8TBZ6	TRIM7	Homo sapiens	Q9C029	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly, Short Stature, And Impaired Glucose Metabolism 1

MSSGM1	Mssgm
Microcephaly, Short Stature, And Impaired Glucose Metabolism

Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Lipodystrophy, Congenital Generalized, Type 1

Congenital Generalized Lipodystrophy Type 1	Bscl1
CGL1	Berardinelli-Seip Congenital Lipodystrophy, Type 1
Brunzell Syndrome Agpat2-Related	Berardinelli-Seip Congenital Lipodystrophy Type 1
Lipodystrophy, Berardinelli-Seip Congenital, Type 1	Brunzell Syndrome, Agpat2-Related
Agpat2-Related Brunzell Syndrome	Congenital Generalized Lipodystrophy 1
Berardinelli-Seip Syndrome	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Total Lipodystrophy And Acromegaloid Gigantism
Lipodystrophy, Generalized, Congenital, Type 1	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15087	TRMT10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRMT10A	VGNC	VGNC:66566
Macaca mulatta	TRMT10A	VGNC	VGNC:107207
Bos taurus	TRMT10A	VGNC	VGNC:36366
Mus musculus	TRMT10A	MGD	MGI:1920421
Rattus norvegicus	TRMT10A	RGD	RGD:1594565
Canis familiaris	TRMT10A	VGNC	VGNC:47851

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