2. Gene
  3. TRIM7 - tripartite motif containing 7 Gene

TRIM7 - tripartite motif containing 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GNIP; RNF90

Gene ID: 81786 | Gene type: protein coding

About TRIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,193,924-181,205,196 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 80 paralogues. Biased expression in skin (RPKM 5.6), esophagus (RPKM 2.8) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRIM7 Products(6)

mRNA Protein Name
NM_033342.4 NP_203128.1 E3 ubiquitin-protein ligase TRIM7 isoform 4
NM_203293.3 NP_976038.1 E3 ubiquitin-protein ligase TRIM7 isoform 1
NM_203294.2 NP_976039.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203295.2 NP_976040.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203296.2 NP_976041.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203297.2 NP_976042.1 E3 ubiquitin-protein ligase TRIM7 isoform 2

TRIM7 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (29 - 81)

zf-B_box

zf-B_box: B-box zinc finger (128 - 166)

PRY

PRY: SPRY-associated domain (344 - 392)

SPRY

SPRY: SPRY domain (394 - 502)

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  • 511 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM7

RING finger protein 90

Related Diseases

Diseases Alias
Noonan Syndrome 7

NS7

Noonan Syndrome, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-159082 E3 ligase Ligand 28 / Unkown
HY-RS15069 TRIM7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM7 VGNC VGNC:36351
Felis catus TRIM7 VGNC VGNC:66552
Macaca mulatta TRIM7 VGNC VGNC:79022
Rattus norvegicus TRIM7 RGD RGD:1307328
Mus musculus TRIM7 MGD MGI:2137353
Canis familiaris TRIM7 VGNC VGNC:47836
Others TRIM7 NCBI