TRIM7 - tripartite motif containing 7 Gene

Homo sapiens

Also known as GNIP; RNF90

Gene ID: 81786 | Gene type: protein coding

About TRIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,193,924-181,205,196 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 80 paralogues. Biased expression in skin (RPKM 5.6), esophagus (RPKM 2.8) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRIM7 Products(6)

mRNA	Protein	Name
NM_033342.4	NP_203128.1	E3 ubiquitin-protein ligase TRIM7 isoform 4
NM_203293.3	NP_976038.1	E3 ubiquitin-protein ligase TRIM7 isoform 1
NM_203294.2	NP_976039.1	E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203295.2	NP_976040.1	E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203296.2	NP_976041.1	E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203297.2	NP_976042.1	E3 ubiquitin-protein ligase TRIM7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	35893676	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	35893676	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35893676	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11331580	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM7 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
511 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM7

RING finger protein 90

TRIM7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM7	Q9C029	CFL2	Homo sapiens	Q9Y281	Validated Y2H	32296183
Intra	TRIM7	Q9C029	IRAK4	Homo sapiens	Q9NWZ3	Validated Y2H	32296183
Intra	TRIM7	Q9C029	CTNNAL1	Homo sapiens	Q9UBT7	Validated Y2H	32296183
Intra	TRIM7	Q9C029	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	TRIM7	Q9C029	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	TRIM7	Q9C029	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183
Intra	TRIM7	Q9C029	MAD2L2	Homo sapiens	Q9UI95	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Noonan Syndrome 7

NS7	Noonan Syndrome, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159082	E3 ligase Ligand 28		/	Unkown
HY-RS15069	TRIM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM7	VGNC	VGNC:36351
Felis catus	TRIM7	VGNC	VGNC:66552
Macaca mulatta	TRIM7	VGNC	VGNC:79022
Rattus norvegicus	TRIM7	RGD	RGD:1307328
Mus musculus	TRIM7	MGD	MGI:2137353
Canis familiaris	TRIM7	VGNC	VGNC:47836
Others	TRIM7	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.