2. Gene
  3. Gpnmb - glycoprotein (transmembrane) nmb Gene

Gpnmb - glycoprotein (transmembrane) nmb Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ipd; Dchil; DC-HIL

Gene ID: 93695 | Gene type: protein coding

About Gpnmb

Summary

Enables heparin binding activity and Integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]

Gpnmb Products(1)

mRNA Protein Name
NM_053110.4 NP_444340.3 transmembrane glycoprotein NMB precursor
Protein Preferred Names Protein Names

transmembrane glycoprotein NMB

dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand

dendritic cell-associated transmembrane protein

iris pigment dispersion

osteoactivin

Recombinant Gpnmb Proteins

Cat. No. Product Name Accession Purity
HY-P77116 GPNMB/Osteoactivin Protein, Mouse (HEK293, His) Q99P91 (K23-N502) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-141604 Glembatumumab vedotin Inhibitor 99.90% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99205 Glembatumumab 99.69% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05648 GPNMB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpnmb NCBI NCBI:10457