Gpnmb - glycoprotein (transmembrane) nmb Gene

Mus musculus

Also known as ipd; Dchil; DC-HIL

Gene ID: 93695 | Gene type: protein coding

About Gpnmb

Summary

Enables heparin binding activity and Integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]

Gpnmb Products(1)

mRNA	Protein	Name
NM_053110.4	NP_444340.3	transmembrane glycoprotein NMB precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	11114299	MGI
enables integrin binding	IDA IDA: Inferred from direct assay	11114299	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	11114299	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17475886	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18036345	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18036345	MGI
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25010402	MGI
involved in regulation of tissue remodeling	IMP IMP: Inferred from mutant phenotype	25010402	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12638126	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11114299	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane glycoprotein NMB

dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand	dendritic cell-associated transmembrane protein
iris pigment dispersion	osteoactivin

Recombinant Gpnmb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77116	GPNMB/Osteoactivin Protein, Mouse (HEK293, His)	Q99P91 (K23-N502)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-141604	Glembatumumab vedotin	Inhibitor	99.90%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99205	Glembatumumab		99.69%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05648	GPNMB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpnmb	NCBI	NCBI:10457

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