SLC22A14 - solute carrier family 22 member 14 Gene

Homo sapiens

Also known as OCTL2; OCTL4; ORCTL4

Gene ID: 9389 | Gene type: protein coding

About SLC22A14

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,278,832-38,318,575 (from NCBI)

This gene has 4 transcripts (splice variants), 482 orthologues and 22 paralogues. Restricted expression toward testis (RPKM 3.4).

Summary

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SLC22A14 Products(2)

mRNA	Protein	Name
NM_001320033.2	NP_001306962.1	solute carrier family 22 member 14
NM_004803.4	NP_004794.2	solute carrier family 22 member 14

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables riboflavin transmembrane transporter activity	IDA IDA: Inferred from direct assay	33882315	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	33882315	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A14 Protein Structure

Sugar_tr

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 14

organic cation transporter-like 4

SLC22A14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC22A14	Q9Y267	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	SLC22A14	Q9Y267	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13067	SLC22A14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC22A14	MGD	MGI:2685974
Felis catus	SLC22A14	VGNC	VGNC:68654
Canis familiaris	SLC22A14	VGNC	VGNC:46275
Rattus norvegicus	SLC22A14	RGD	RGD:1306470
Bos taurus	SLC22A14	VGNC	VGNC:34722
Macaca mulatta	SLC22A14	VGNC	VGNC:77594

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