2. Gene
  3. TGFBRAP1 - transforming growth factor beta receptor associated protein 1 Gene

TGFBRAP1 - transforming growth factor beta receptor associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as VPS3; TRAP1; TRAP-1

Gene ID: 9392 | Gene type: protein coding

About TGFBRAP1

Cytogenetic location: 2q12.1-q12.2 Genomic coordinates (GRCh38): 2:105,249,404-105,329,735 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.3), thyroid (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

TGFBRAP1 Products(3)

mRNA Protein Name
NM_001142621.3 NP_001136093.1 transforming growth factor-beta receptor-associated protein 1 isoform 1
NM_001328646.3 NP_001315575.1 transforming growth factor-beta receptor-associated protein 1 isoform 2
NM_004257.6 NP_004248.2 transforming growth factor-beta receptor-associated protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SMAD binding IDA
IDA: Inferred from direct assay
11278302 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11278302 GOA
enables transforming growth factor beta receptor binding IDA
IDA: Inferred from direct assay
11278302 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endosomal vesicle fusion IMP
IMP: Inferred from mutant phenotype
25266290 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
25266290 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11278302 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
11278302 GOA
Cellular Component GO Annotation Evidence Reference Source
located in early endosome IDA
IDA: Inferred from direct assay
25266290 GOA
located in membrane IDA
IDA: Inferred from direct assay
11278302 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFBRAP1 Protein Structure

CNH

CNH: CNH domain (76 - 286)

Vps39_1

Vps39_1: Vacuolar sorting protein 39 domain 1 (448 - 550)

Clathrin

Clathrin: Region in Clathrin and VPS (573 - 700)

Vps39_2

Vps39_2: Vacuolar sorting protein 39 domain 2 (738 - 845)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 860 a.a.
Protein Preferred Names Protein Names

transforming growth factor-beta receptor-associated protein 1

TGF-beta receptor-associated protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14454 TGFBRAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TGFBRAP1 VGNC VGNC:35806
Canis familiaris TGFBRAP1 VGNC VGNC:47313
Rattus norvegicus TGFBRAP1 RGD RGD:1310772
Felis catus TGFBRAP1 VGNC VGNC:66138
Mus musculus TGFBRAP1 MGD MGI:2447427
Macaca mulatta TGFBRAP1 VGNC VGNC:78396