NMT2 - N-myristoyltransferase 2 Gene

Homo sapiens

Gene ID: 9397 | Gene type: protein coding

About NMT2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,105,700-15,168,693 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

NMT2 Products(2)

mRNA	Protein	Name
NM_001308295.2	NP_001295224.1	glycylpeptide N-tetradecanoyltransferase 2 isoform 2
NM_004808.3	NP_004799.1	glycylpeptide N-tetradecanoyltransferase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycylpeptide N-tetradecanoyltransferase activity	IDA IDA: Inferred from direct assay	25255805	GOA
enables peptidyl-lysine N6-myristoyltransferase activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16530191	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-terminal peptidyl-glycine N-myristoylation	IDA IDA: Inferred from direct assay	25255805	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9506952	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9506952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMT2 Protein Structure

NMT

NMT_C

0
100
200
300
400
498 a.a.

Protein Preferred Names

Protein Names

glycylpeptide N-tetradecanoyltransferase 2

NMT 2

Related Diseases

Diseases

Alias

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147308	PCLX-001	Activator	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112258	IMP-1088	Inhibitor	99.16%	Unkown
HY-RS09390	NMT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NMT2	MGD	MGI:1202298
Canis familiaris	NMT2	VGNC	VGNC:52219
Rattus norvegicus	NMT2	RGD	RGD:1303175
Felis catus	NMT2	VGNC	VGNC:68508
Macaca mulatta	NMT2	VGNC	VGNC:75361
Bos taurus	NMT2	VGNC	VGNC:32138
Others	NMT2	NCBI

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