ZRANB2 - zinc finger RANBP2-type containing 2 Gene

Homo sapiens

Also known as ZIS; ZIS1; ZIS2; ZNF265

Gene ID: 9406 | Gene type: protein coding

About ZRANB2

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:71,063,291-71,081,035 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in endometrium (RPKM 47.3), lymph node (RPKM 37.7) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZRANB2 Products(2)

mRNA	Protein	Name
NM_005455.5	NP_005446.2	zinc finger Ran-binding domain-containing protein 2 isoform 2
NM_203350.3	NP_976225.1	zinc finger Ran-binding domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16982639	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZRANB2 Protein Structure

zf-RanBP

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

zinc finger Ran-binding domain-containing protein 2

zinc finger protein 265

ZRANB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZRANB2	O95218	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927
Intra	ZRANB2	O95218	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	17620599

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acute Dacryoadenitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16194	ZRANB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZRANB2	VGNC	VGNC:37372
Canis familiaris	ZRANB2	VGNC	VGNC:48848
Felis catus	ZRANB2	VGNC	VGNC:67380
Rattus norvegicus	ZRANB2	RGD	RGD:61854
Mus musculus	ZRANB2	MGD	MGI:1858211

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