Tnfrsf21 - tumor necrosis factor receptor superfamily, member 21 Gene

Mus musculus

Also known as DR6; TR7

Gene ID: 94185 | Gene type: protein coding

About Tnfrsf21

Summary

Involved in several processes, including negative regulation of cytokine production; negative regulation of lymphocyte proliferation; and oligodendrocyte apoptotic process. Located in axon. Is intrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; lung; metanephros; nervous system; and nose. Orthologous to human TNFRSF21 (TNF Receptor Superfamily member 21). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf21 Products(1)

mRNA	Protein	Name
NM_178589.3	NP_848704.1	tumor necrosis factor receptor superfamily member 21 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12515813	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in adaptive immune response	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in humoral immune response	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	21725297	MGI
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12515813	MGI
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in negative regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in negative regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	11485735	MGI
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23559013	MGI
involved in oligodendrocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	21725297	MGI
involved in regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	21725297	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12515813	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 21

Death receptor 6

TNFR-related death receptor-6

Recombinant Tnfrsf21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72664	DR6/TNFRSF21 Protein, Mouse (HEK293, Fc-His)	Q9EPU5 (Q42-H349)	≥95%
HY-P75278	DR6/TNFRSF21 Protein, Mouse (HEK293, His)	Q9EPU5 (Q42-H349)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14812	TNFRSF21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990526	Anti-TNFRSF21/DR6/CD358 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfrsf21	NCBI	NCBI:27242
Macaca fascicularis	Tnfrsf21	NCBI	NCBI:101925746
Rattus norvegicus	Tnfrsf21	NCBI	NCBI:316256

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