NCR2 - natural cytotoxicity triggering receptor 2 Gene

Homo sapiens

Also known as LY95; CD336; NKP44; NK-p44; dJ149M18.1

Gene ID: 9436 | Gene type: protein coding

About NCR2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,335,608-41,350,889 (from NCBI)

This gene has 3 transcripts (splice variants), 74 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable signaling receptor activity. Predicted to be involved in cellular defense response and signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

NCR2 Products(3)

mRNA	Protein	Name
NM_001199509.2	NP_001186438.1	natural cytotoxicity triggering receptor 2 isoform 2 precursor
NM_001199510.2	NP_001186439.1	natural cytotoxicity triggering receptor 2 isoform 3 precursor
NM_004828.4	NP_004819.2	natural cytotoxicity triggering receptor 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10049942	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR2 Protein Structure

V-set

0
100
200
276 a.a.

Protein Preferred Names

Protein Names

natural cytotoxicity triggering receptor 2

NK cell activating receptor (NKp44)

NCR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NCR2	O95944	KMT2E	Homo sapiens	Q8IZD2-8	LexA B52 Complement	23958951
Intra	NCR2	O95944	KMT2E	Homo sapiens	Q8IZD2-8	Anti Bait CoIP	23958951
Intra	NCR2	O95944	KMT2E	Homo sapiens	Q8IZD2-8	Far-WB	23958951
Intra	NCR2	O95944	TYROBP	Homo sapiens	O43914	Anti Bait CoIP	14707061
Intra	NCR2	O95944	TYROBP	Homo sapiens	O43914	Anti Bait CoIP	10049942

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72502	NKp44/NCR2 Protein, Human (HEK293, His)	O95944/NP_004819.2 (Q22-P190)	≥95%
HY-P74685	NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His)	O95944 (Q22-P190)	≥95%

Related Diseases

Diseases

Alias

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Nk Cell Deficiency

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09099	NCR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCR2	RGD	RGD:1311406
Felis catus	NCR2	VGNC	VGNC:102474
Macaca mulatta	NCR2	VGNC	VGNC:75066
Others	NCR2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.