2. Gene
  3. KHDRBS3 - KH RNA binding domain containing, signal transduction associated 3 Gene

KHDRBS3 - KH RNA binding domain containing, signal transduction associated 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile

Gene ID: 10656 | Gene type: protein coding

About KHDRBS3

Cytogenetic location: 8q24.23 Genomic coordinates (GRCh38): 8:135,457,456-135,656,516 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 4 paralogues. Biased expression in testis (RPKM 33.1), brain (RPKM 14.0) and 10 other tissues.

Summary

Enables RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and spermatogenesis. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

KHDRBS3 Products(1)

mRNA Protein Name
NM_006558.3 NP_006549.1 KH domain-containing, RNA-binding, signal transduction-associated protein 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
19561594 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
10332027 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10332027 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10332027 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IMP
IMP: Inferred from mutant phenotype
10332027 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
10332027 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

KH domain-containing, RNA-binding, signal transduction-associated protein 3

KH domain containing, RNA binding, signal transduction associated 3

KHDRBS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KHDRBS3 O75525 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra KHDRBS3 O75525 MARK4 Homo sapiens Q6IPE9
Validated Y2H
25416956
Intra KHDRBS3 O75525 MARK4 Homo sapiens Q6IPE9
Y2H Array
25416956
Intra KHDRBS3 O75525 MARK4 Homo sapiens Q6IPE9
Y2H Prey Pooling
25416956
Intra KHDRBS3 O75525 PCDHB14 Homo sapiens Q9Y5E9
Validated Y2H
32296183
Intra KHDRBS3 O75525 RFC3 Homo sapiens P40938
Validated Y2H
32296183
Intra KHDRBS3 O75525 LMNTD2 Homo sapiens Q8IXW0
Validated Y2H
32296183
Intra KHDRBS3 O75525 KHDRBS1 Homo sapiens Q07666
Y2H
22365833
Intra KHDRBS3 O75525 INPP5D Homo sapiens Q92835
Validated Y2H
25416956
Intra KHDRBS3 O75525 TYK2 Homo sapiens P29597
Validated Y2H
32296183
Intra KHDRBS3 O75525 ZNF575 Homo sapiens Q86XF7
Validated Y2H
32296183
Intra KHDRBS3 O75525 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra KHDRBS3 O75525 PRPF31 Homo sapiens Q8WWY3
Y2H Prey Pooling
25416956
Intra KHDRBS3 O75525 PRPF31 Homo sapiens Q8WWY3
Y2H Array
25416956
Intra KHDRBS3 O75525 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
25416956
Intra KHDRBS3 O75525 SHANK3 Homo sapiens Q9BYB0
Anti Tag CoIP
21653829
Intra KHDRBS3 O75525 SHANK3 Homo sapiens Q9BYB0
Y2H Pooling
21653829
Intra KHDRBS3 O75525 ZNF326 Homo sapiens Q5BKZ1
Validated Y2H
32296183
Intra KHDRBS3 O75525 PRR3 Homo sapiens P79522
Validated Y2H
32296183
Intra KHDRBS3 O75525 YTHDC1 Homo sapiens Q96MU7
Validated Y2H
32296183
Intra KHDRBS3 O75525 YTHDC1 Homo sapiens Q96MU7
Validated Y2H
25416956
Intra KHDRBS3 O75525 YTHDC1 Homo sapiens Q96MU7
Y2H Prey Pooling
25416956
Intra KHDRBS3 O75525 YTHDC1 Homo sapiens Q96MU7
Y2H Array
25416956
Intra KHDRBS3 O75525 RPH3AL Homo sapiens Q9UNE2
Validated Y2H
32296183
Intra KHDRBS3 O75525 MYPOP Homo sapiens Q86VE0
Validated Y2H
32296183
Intra KHDRBS3 O75525 RBM3 Homo sapiens P98179
Validated Y2H
32296183
Intra KHDRBS3 O75525 SNX18 Homo sapiens Q96RF0
Validated Y2H
32296183
Intra KHDRBS3 O75525 RASAL3 Homo sapiens Q86YV0
Validated Y2H
32296183
Intra KHDRBS3 O75525 ZNF408 Homo sapiens Q9H9D4
Validated Y2H
32296183
Intra KHDRBS3 O75525 ZNF408 Homo sapiens Q9H9D4
Y2H Pooling
16189514
Intra KHDRBS3 O75525 NELFB Homo sapiens Q8WX92
TAP
20195357
Intra KHDRBS3 O75525 NELFB Homo sapiens Q8WX92
Display Tech
20195357
Intra KHDRBS3 O75525 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra KHDRBS3 O75525 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra KHDRBS3 O75525 DOCK2 Homo sapiens Q92608
Validated Y2H
32296183
Intra KHDRBS3 O75525 HNRNPK Homo sapiens P61978-2
Validated Y2H
32296183
Intra KHDRBS3 O75525 HBZ Homo sapiens P02008
Validated Y2H
32296183
Intra KHDRBS3 O75525 RASD1 Homo sapiens Q9Y272
Validated Y2H
32296183
Intra KHDRBS3 O75525 CNNM3 Homo sapiens Q8NE01
Validated Y2H
32296183
Intra KHDRBS3 O75525 BAHD1 Homo sapiens Q8TBE0
Y2H Prey Pooling
25416956
Intra KHDRBS3 O75525 BAHD1 Homo sapiens Q8TBE0
Y2H Pooling
16189514
Intra KHDRBS3 O75525 BAHD1 Homo sapiens Q8TBE0
Validated Y2H
25416956
Intra KHDRBS3 O75525 KHDRBS2 Homo sapiens Q5VWX1
Y2H Pooling
16189514
Intra KHDRBS3 O75525 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
32296183
Intra KHDRBS3 O75525 RBMX Homo sapiens P38159
Y2H Pooling
16189514
Intra KHDRBS3 O75525 RBMX Homo sapiens P38159
Validated Y2H
32296183
Intra KHDRBS3 O75525 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra KHDRBS3 O75525 ZNF580 Homo sapiens Q9UK33
Validated Y2H
32296183
Intra KHDRBS3 O75525 INPP5D Homo sapiens Q92835-2
Validated Y2H
32296183
Intra KHDRBS3 O75525 DMRT3 Homo sapiens Q9NQL9
Y2H Prey Pooling
25416956
Intra KHDRBS3 O75525 DMRT3 Homo sapiens Q9NQL9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypophosphatasia, Adult

Adult Hypophosphatasia

Odontohypophosphatasia

Hypophosphatasia, Mild

HPPA

Hypophosphatasia

Mild Hypophosphatasia

Adult Rathbun Disease

Adult Phosphoethanolaminuria

HOPS
Localized Osteosarcoma

Localised Osteogenic Sarcoma

Localised Osteosarcoma

Localized Osteogenic Sarcoma
Tick Infestation

Tick Infestations
Hypophosphatasia

Phosphoethanolaminuria

Childhood Hypophosphatasia

Deficiency Of Alkaline Phosphatase

Hypophospatasia, Childhood

Hypophosphatasia Mild

Phosphoethanol-Aminuria

Rathburn Disease

Hpp

Rathbun Disease

Hypophosphatasia, Childhood

Infantile Hypophosphatasia
Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07239 KHDRBS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KHDRBS3 VGNC VGNC:63079
Canis familiaris KHDRBS3 VGNC VGNC:42337
Macaca mulatta KHDRBS3 VGNC VGNC:73849
Rattus norvegicus KHDRBS3 RGD RGD:620921
Bos taurus KHDRBS3 VGNC VGNC:30542
Mus musculus KHDRBS3 MGD MGI:1313312