ADAMTS1 - ADAM metallopeptidase with thrombospondin type 1 motif 1 Gene

Homo sapiens

Also known as C3-C5; METH1

Gene ID: 9510 | Gene type: protein coding

About ADAMTS1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:26,835,755-26,845,409 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 25 paralogues. Broad expression in ovary (RPKM 126.2), placenta (RPKM 77.2) and 17 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of Cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

ADAMTS1 Products(1)

mRNA	Protein	Name
NM_006988.5	NP_008919.3	A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	11278559	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	10438512	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	28890348	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	28890348	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	28890348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTS1 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

0
200
400
600
800
967 a.a.

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 1

ADAM-TS 1

ADAMTS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADAMTS1	Q9UHI8	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	ADAMTS1	Q9UHI8	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	ADAMTS1	Q9UHI8	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Cross	ADAMTS1	Q9UHI8	ns8_sars2	SARS-CoV-2	P0DTC8	Y2H Array	36217030
Intra	ADAMTS1	Q9UHI8	PSMD9	Homo sapiens	O00233	Validated Y2H	32814053
Intra	ADAMTS1	Q9UHI8	PSMD9	Homo sapiens	O00233	Y2H Array	32814053
Intra	ADAMTS1	Q9UHI8	PSMD9	Homo sapiens	O00233	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Ureteral Obstruction

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Cardiomyopathy, Dilated, 1l

Dilated Cardiomyopathy 1l	CMD1L
Cardiomyopathy, Dilated 1l	Cardiomyopathy, Dilated, Type 1l

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Marfan Syndrome

MFS	Mfs1
Marfan'S Syndrome	Marfan Syndrome Type 1
Marfan Syndrome, Type I	Mass Phenotype
Contractural Arachnodactyly	Mass Syndrome
Octd	Overlap Connective Tissue Disease
Marfanoid Hypermobility Syndrome	Marfan Disease

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00291	ADAMTS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAMTS1	RGD	RGD:621241
Felis catus	ADAMTS1	VGNC	VGNC:59587
Canis familiaris	ADAMTS1	VGNC	VGNC:37590
Macaca mulatta	ADAMTS1	VGNC	VGNC:80327
Mus musculus	ADAMTS1	MGD	MGI:109249
Bos taurus	ADAMTS1	VGNC	VGNC:25614
Others	ADAMTS1	NCBI

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