CIR1 - corepressor interacting with RBPJ, CIR1 Gene

Homo sapiens

Also known as CIR

Gene ID: 9541 | Gene type: protein coding

About CIR1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,348,022-174,395,712 (from NCBI)

This gene has 5 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 20.7), testis (RPKM 18.7) and 25 other tissues.

Summary

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome. [provided by Alliance of Genome Resources, Apr 2022]

CIR1 Products(1)

mRNA	Protein	Name
NM_004882.4	NP_004873.3	corepressor interacting with RBPJ 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	9874765	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9874765	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9874765	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9874765	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9874765	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9874765	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9874765	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	15652350	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9874765	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIR1 Protein Structure

Cir_N

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

corepressor interacting with RBPJ 1

CBF1 (RBPJ) interacting corepressor 1

CIR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIR1	Q86X95	SRSF2	Homo sapiens	Q01130	Anti Tag CoIP	15652350
Intra	CIR1	Q86X95	SRSF2	Homo sapiens	Q01130	Y2H	15652350
Intra	CIR1	Q86X95	U2AF1	Homo sapiens	Q01081	Y2H	15652350
Intra	CIR1	Q86X95	U2AF1	Homo sapiens	Q01081	Pull Down	15652350

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodermatitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02720	CIR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIR1	RGD	RGD:1309199
Felis catus	CIR1	VGNC	VGNC:60907
Macaca mulatta	CIR1	VGNC	VGNC:71331
Mus musculus	CIR1	MGD	MGI:1914185
Bos taurus	CIR1	VGNC	VGNC:59328

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