PDIA4 - protein disulfide isomerase family A member 4 Gene

Homo sapiens

Also known as ERP70; ERP72; ERp-72

Gene ID: 9601 | Gene type: protein coding

About PDIA4

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:149,003,051-149,028,505 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 13 paralogues. Broad expression in thyroid (RPKM 166.5), liver (RPKM 67.6) and 24 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to Cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

PDIA4 Products(3)

mRNA	Protein	Name
NM_001371244.1	NP_001358173.1	protein disulfide-isomerase A4 isoform 1 precursor
NM_001371245.1	NP_001358174.1	protein disulfide-isomerase A4 isoform 3 precursor
NM_004911.5	NP_004902.1	protein disulfide-isomerase A4 isofrom 2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16287128	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	16677074	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19995400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA4 Protein Structure

Thioredoxin

Thioredoxin_6

Thioredoxin

0
100
200
300
400
500
600
645 a.a.

Protein Preferred Names

Protein Names

protein disulfide-isomerase A4

ER protein 70

Recombinant PDIA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71113	PDIA4 Protein, Human (HEK293, His)	P13667 (V21-L645)	≥95%

Related Diseases

Diseases

Alias

Multiple Epiphyseal Dysplasia

Med	Polyepiphyseal Dysplasia
Edm	Epiphyseal Dysplasia, Multiple, 1
Epiphyseal Dysplasia, Multiple, 2	Epiphyseal Dysplasia, Multiple, 3
Epiphyseal Dysplasia, Multiple, 4	Epiphyseal Dysplasia, Multiple, 5
Epiphyseal Dysplasia, Multiple	Edm1
Edm2	Edm3
Edm4	Edm5
Epiphyseal Dysplasia, Fairbank Type	Epiphyseal Dysplasia, Ribbing Type
Multiple Epiphyseal Dysplasia, Autosomal Dominant	Multiple Epiphyseal Dysplasia, Autosomal Recessive
Rmed	Dysplasia, Epiphyseal, Multiple
Osteochondrodysplasias

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Ovarian Dysgenesis 2

Premature Ovarian Failure 4	ODG2
Ovarian Dysgenesis, Hypergonadotropic, X-Linked	Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis
Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis	X-Linked Hypergonadotropic Ovarian Dysgenesis
POF4	Dysgenesis, Ovarian, Type 2

Epiphyseal Dysplasia, Multiple, 5

EDM5	Multiple Epiphyseal Dysplasia 5
Bhmed	Multiple Epiphyseal Dysplasia Type 5
Multiple Epiphyseal Dysplasia, Matn3-Related	Microepiphyseal Dysplasia, Bilateral Hereditary
Bilateral Hereditary Microepiphyseal Dysplasia	Multiple Epiphyseal Dysplasia Matn3-Related
Epiphyseal Dysplasia Multiple 5	Multiple Epiphyseal Dysplasia, Matn3 Related
Bilateral Hereditary Micro-Epiphyseal Dysplasia	Med5
Polyepiphyseal Dysplasia Type 5	Dysplasia, Epiphyseal, Multiple, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122895	E64FC26		98.10%	Unkown
HY-122895A	(E/Z)-E64FC26		98.09%	Unkown
HY-RS10269	PDIA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDIA4	VGNC	VGNC:64084
Mus musculus	PDIA4	MGD	MGI:104864
Macaca mulatta	PDIA4	VGNC	VGNC:84750
Canis familiaris	PDIA4	VGNC	VGNC:44377
Bos taurus	PDIA4	VGNC	VGNC:32698
Rattus norvegicus	PDIA4	RGD	RGD:619835
Others	PDIA4	NCBI

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