2. Gene
  3. NFE2L3 - NFE2 like bZIP transcription factor 3 Gene

NFE2L3 - NFE2 like bZIP transcription factor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NRF3

Gene ID: 9603 | Gene type: protein coding

About NFE2L3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,152,198-26,187,137 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 3 paralogues. Broad expression in placenta (RPKM 30.4), appendix (RPKM 7.6) and 16 other tissues.

Summary

This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

NFE2L3 Products(1)

mRNA Protein Name
NM_004289.7 NP_004280.5 nuclear factor erythroid 2-related factor 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFE2L3 Protein Structure

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (549 - 638)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
Protein Preferred Names Protein Names

nuclear factor erythroid 2-related factor 3

NF-E2-related factor 3

NFE2L3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NFE2L3 Q9Y4A8 MAFG Homo sapiens O15525
FRET
23661758
Intra NFE2L3 Q9Y4A8 MAFG Homo sapiens O15525
Anti Tag CoIP
33961781
Intra NFE2L3 Q9Y4A8 MAFG Homo sapiens O15525
Anti Tag CoIP
28514442
Intra NFE2L3 Q9Y4A8 MAFG Homo sapiens O15525
Peptide Array
20102225
Intra NFE2L3 Q9Y4A8 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra NFE2L3 Q9Y4A8 NFE2 Homo sapiens Q16621
Peptide Array
20102225
Intra NFE2L3 Q9Y4A8 NFE2 Homo sapiens Q16621
FRET
23661758
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09248 NFE2L3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NFE2L3 MGD MGI:1339958
Rattus norvegicus NFE2L3 RGD RGD:1307730
Bos taurus NFE2L3 VGNC VGNC:32037
Canis familiaris NFE2L3 VGNC VGNC:43774
Macaca mulatta NFE2L3 VGNC VGNC:75333
Felis catus NFE2L3 VGNC VGNC:68476