MAFF - MAF bZIP transcription factor F Gene

Homo sapiens

Also known as U-MAF; hMafF

Gene ID: 23764 | Gene type: protein coding

About MAFF

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,201,994-38,216,511 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 6 paralogues. Ubiquitous expression in gall bladder (RPKM 22.1), fat (RPKM 18.9) and 25 other tissues.

Summary

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the Oxytocin Receptor (OTR) gene and most likely heterodimerizes with Other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

MAFF Products(4)

mRNA	Protein	Name
NM_001161572.2	NP_001155044.1	transcription factor MafF isoform a
NM_001161573.1	NP_001155045.1	transcription factor MafF isoform a
NM_001161574.2	NP_001155046.1	transcription factor MafF isoform b
NM_012323.4	NP_036455.1	transcription factor MafF isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12490281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8932385	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12490281	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAFF Protein Structure

bZIP_Maf

0
100
164 a.a.

Protein Preferred Names

Protein Names

transcription factor MafF

v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F

MAFF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAFF	Q9ULX9	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	Anti Tag CoIP	28514442
Intra	MAFF	Q9ULX9	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	FRET	23661758
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	28514442
Intra	MAFF	Q9ULX9	NFE2L2	Homo sapiens	Q16236	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L1	Homo sapiens	Q14494	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L1	Homo sapiens	Q14494	FRET	23661758
Intra	MAFF	Q9ULX9	NFIL3	Homo sapiens	Q16649	FRET	23661758
Intra	MAFF	Q9ULX9	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	MAFF	Q9ULX9	MAFG	Homo sapiens	O15525	FRET	23661758
Intra	MAFF	Q9ULX9	BATF2	Homo sapiens	Q8N1L9	FRET	23661758

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma	Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type
Finkel Disease	Smafk
Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant	Autosomal Dominant Adult Proximal Spinal Muscular Atrophy
Finkel Late-Adult Type Sma

Multicentric Carpotarsal Osteolysis Syndrome

Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy	MCTO
Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy	Idiopathic Multicentric Osteolysis With Or Without Nephropathy
Autosomal Dominant Multicentric Osteolysis	Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy
Multicentric Osteolysis, Autosomal Dominant	Multicentric Osteolysis Nephropathy
Osteolysis, Carpotarsal, Multicentric Syndrome	Lytic Lesion

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07960	MAFF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAFF	VGNC	VGNC:31140
Macaca mulatta	MAFF	VGNC	VGNC:95357
Mus musculus	MAFF	MGD	MGI:96910
Rattus norvegicus	MAFF	RGD	RGD:1309531
Canis familiaris	MAFF	VGNC	VGNC:49919

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