CARTPT - CART prepropeptide Gene

Homo sapiens

Also known as CART

Gene ID: 9607 | Gene type: protein coding

About CARTPT

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:71,719,275-71,721,045 (from NCBI)

This gene has 2 transcripts (splice variants), 270 orthologues and is associated with 1 phenotype. Biased expression in adrenal (RPKM 51.3), brain (RPKM 5.7) and 1 other tissue.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active Peptides. These Peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]

CARTPT Products(1)

mRNA	Protein	Name
NM_004291.4	NP_004282.1	cocaine- and amphetamine-regulated transcript protein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	11711504	GOA
involved in negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	16614075	GOA
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	11711504	GOA
involved in positive regulation of epinephrine secretion	IDA IDA: Inferred from direct assay	11711504	GOA
involved in positive regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	11711504	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11711504	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	21624661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARTPT Protein Structure

CART

0
100
116 a.a.

Protein Preferred Names

Protein Names

cocaine- and amphetamine-regulated transcript protein

Recombinant CARTPT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74350	CART Protein, Human (HEK293, Fc)	Q16568 (Q28-L116)	≥95%
HY-P74351	CART Protein, Human (HEK293)	Q16568/NP_004282.1 (Q28-L116)	≥95%

Related Diseases

Diseases

Alias

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01935	CARTPT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CARTPT	VGNC	VGNC:60375
Macaca mulatta	CARTPT	VGNC	VGNC:70619
Rattus norvegicus	CARTPT	RGD	RGD:2272
Mus musculus	CARTPT	MGD	MGI:1351330
Bos taurus	CARTPT	VGNC	VGNC:26774
Canis familiaris	CARTPT	VGNC	VGNC:38727
Others	CARTPT	NCBI

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