CTR9 - CTR9 homolog, Paf1/RNA polymerase II complex component Gene

Homo sapiens

Also known as TSBP; p150; SH2BP1; p150TSP

Gene ID: 9646 | Gene type: protein coding

About CTR9

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:10,751,246-10,779,746 (from NCBI)

This gene has 6 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 19.1), thyroid (RPKM 14.8) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modification of histones. [provided by RefSeq, Oct 2016]

CTR9 Products(2)

mRNA	Protein	Name
NM_001346279.2	NP_001333208.1	RNA polymerase-associated protein CTR9 homolog isoform 2
NM_014633.5	NP_055448.1	RNA polymerase-associated protein CTR9 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	20541477	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16307923	GOA
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	19345177	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	20178742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cdc73/Paf1 complex	IDA IDA: Inferred from direct assay	16307923	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTR9 Protein Structure

TPR_11

TPR_2

TPR_1

TPR_11

TPR_1

0
200
400
600
800
1000
1173 a.a.

Protein Preferred Names

Protein Names

RNA polymerase-associated protein CTR9 homolog

Ctr9, Paf1/RNA polymerase II complex component, homolog

Related Diseases

Diseases

Alias

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03316	CTR9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CTR9	VGNC	VGNC:61262
Rattus norvegicus	CTR9	RGD	RGD:1311097
Canis familiaris	CTR9	VGNC	VGNC:39706
Bos taurus	CTR9	VGNC	VGNC:27810
Mus musculus	CTR9	MGD	MGI:109345
Macaca mulatta	CTR9	VGNC	VGNC:71424

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