GCC2 - GRIP and coiled-coil domain containing 2 Gene

Homo sapiens

Also known as REN53; GCC185; RANBP2L4

Gene ID: 9648 | Gene type: protein coding

About GCC2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,449,206-108,509,415 (from NCBI)

This gene has 25 transcripts (splice variants), 192 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 11.9), thyroid (RPKM 11.7) and 25 other tissues.

Summary

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GCC2 Products(2)

mRNA	Protein	Name
NM_001410194.1	NP_001397123.1	GRIP and coiled-coil domain-containing protein 2 isoform 2
NM_181453.4	NP_852118.2	GRIP and coiled-coil domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18243103	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16885419	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi ribbon formation	IMP IMP: Inferred from mutant phenotype	16885419	GOA
NOT involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	16885419	GOA
involved in late endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	16885419	GOA
involved in microtubule anchoring	IMP IMP: Inferred from mutant phenotype	17543864	GOA
involved in microtubule organizing center organization	IMP IMP: Inferred from mutant phenotype	17543864	GOA
involved in protein localization to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	16885419	GOA
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	16885419	GOA
involved in recycling endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	17488291	GOA
involved in regulation of protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	17488291	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	17488291	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18243103	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	16885419	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCC2 Protein Structure

GRIP

0
300
600
900
1200
1500
1684 a.a.

Protein Preferred Names

Protein Names

GRIP and coiled-coil domain-containing protein 2

185 kDa Golgi coiled-coil protein

GCC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GCC2	Q8IWJ2	RAB6A	Homo sapiens	P20340	Affinity Chrom	18243103
Intra	GCC2	Q8IWJ2	RAB6A	Homo sapiens	P20340	ITC	18243103
Intra	GCC2	Q8IWJ2	RAB9A	Canis familiaris	P24408	Affinity Chrom	18243103
Intra	GCC2	Q8IWJ2	RAB9A	Canis familiaris	P24408	ITC	18243103

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z	Charcot-Marie-Tooth Disease Axonal Type 2z
Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z	Charcot-Marie-Tooth Neuropathy, Type 2z
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z	Charcot-Marie-Tooth Neuropathy Type 2z
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation
Charcot-Marie-Tooth Disease 2z	Charcot-Marie-Tooth Disease, Type 2z

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05320	GCC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GCC2	VGNC	VGNC:41140
Bos taurus	GCC2	VGNC	VGNC:29281
Felis catus	GCC2	VGNC	VGNC:62488
Mus musculus	GCC2	MGD	MGI:1917547
Macaca mulatta	GCC2	VGNC	VGNC:72765
Rattus norvegicus	GCC2	RGD	RGD:1305732

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