CD63 - CD63 molecule Gene

Homo sapiens

Also known as MLA1; ME491; LAMP-3; OMA81H; TSPAN30

Gene ID: 967 | Gene type: protein coding

About CD63

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,725,323-55,729,673 (from NCBI)

This gene has 16 transcripts (splice variants), 207 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 184.8), colon (RPKM 181.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

CD63 Products(16)

mRNA	Protein	Name
NM_001257389.2	NP_001244318.1	CD63 antigen isoform A
NM_001257390.2	NP_001244319.1	CD63 antigen isoform A
NM_001257391.2	NP_001244320.1	CD63 antigen isoform A
NM_001257392.1	NP_001244321.1	CD63 antigen isoform C
NM_001257400.2	NP_001244329.1	CD63 antigen isoform D precursor
NM_001257401.2	NP_001244330.1	CD63 antigen isoform D precursor
NM_001267698.2	NP_001254627.1	CD63 antigen isoform A
NM_001413281.1	NP_001400210.1	CD63 antigen isoform A
NM_001413282.1	NP_001400211.1	CD63 antigen isoform A
NM_001413283.1	NP_001400212.1	CD63 antigen isoform A
NM_001413284.1	NP_001400213.1	CD63 antigen isoform A
NM_001413285.1	NP_001400214.1	CD63 antigen isoform A
NM_001413286.1	NP_001400215.1	CD63 antigen isoform D precursor
NM_001413287.1	NP_001400216.1	CD63 antigen isoform E
NM_001413288.1	NP_001400217.1	CD63 antigen isoform F
NM_001780.6	NP_001771.1	CD63 antigen isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16917503	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	23632027	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	23632027	GOA
involved in endosome to melanosome transport	IMP IMP: Inferred from mutant phenotype	21962903	GOA
involved in pigment granule maturation	IMP IMP: Inferred from mutant phenotype	21962903	GOA
involved in positive regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16917503	GOA
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	23632027	GOA
acts upstream of or within regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	15647390	GOA
involved in regulation of vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	23632027	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15647390	GOA
located in endosome lumen	IDA IDA: Inferred from direct assay	22660413	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15229288	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15908444	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	23632027	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	22431521	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	26280656	GOA
located in multivesicular body, internal vesicle	IDA IDA: Inferred from direct assay	21962903	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16917503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD63 Protein Structure

Tetraspannin

0
100
200
238 a.a.

Protein Preferred Names

Protein Names

CD63 antigen

CD63 antigen (melanoma 1 antigen)

Recombinant CD63 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72715	CD63 Protein, Human/Cynomolgus (HEK293, N-His)	P08962-1/NP_001253224 (A103-V203)	≥95%

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Storage Pool Platelet Disease

Platelet Storage Pool Deficiency	Storage Pool Disease Of Platelets
Dense Body Defect	Platelet Dense Granule Deficiency
Platelet Storage Pool Defect	Platelet Storage Pool Diseases
Alpha Delta Granule Deficiency	Alpha Dense Granule Deficiency
Combined Alpha-Delta Platelet Storage Pool Deficiency

Chediak-Higashi Syndrome

CHS	Chédiak-Higashi Syndrome
Chediak - Steinbrinck Anomaly	Chediak Higashi Syndrome
Chediak-Steinbrinck-Higashi Syndrome	Oculocutaneous Albinism With Leukocyte Defect
Chediak-Higashi Disease	Chediak-Higashi-Steinbrink Syndrome

Diclofenac Allergy

Voltaren Allergy

Oculocutaneous Albinism

Albinism, Oculocutaneous	Oca
Albinism Oculocutaneous	Oca - [Oculocutaneous Albinism]

Ocular Melanoma

Intraocular Melanoma	Uveal Melanoma
Eye Melanoma	Melanoma Of Eye
Melanoma Of The Uvea	Malignant Melanoma Of Eye

Amoxicillin Allergy

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Quebec Platelet Disorder

Factor V Quebec	QPD
Bdplt5	Bleeding Disorder, Platelet-Type, 5
Platelet-Type Bleeding Disorder 5	Bleeding Disorder Platelet-Type 5
Platelet Disorder, Quebec

Rocuronium Allergy

Esmeron Allergy

Zemuron Allergy

Congenital Myasthenic Syndrome 7

Cms7	Congenital Myasthenic Syndrome 7 Presynaptic
Myasthenic Syndrome, Congenital, Type 7, Presynaptic

Diphtheria

Corynebacterium Infections	Corynebacterium Infection
Diphtherial Infection	Infection Due To Corynebacterium Diphtheriae

Von Willebrand'S Disease

Von Willebrand Disease	Von Willebrand Disorder
Vascular Pseudohemophilia	Hereditary Von Willebrand Disease
Vwd	Vascular Hemophilia
Von Willebrand'S-Jurgens' Disease	Von Willebrand-Jrgens Disease
Von Willebrand Factor Deficiency	Von Willebrand Factor, Deficiency
Angiohemophilia	Von Willebrand'S Factor Deficiency
Von Willebrand Diseases	Factor Viii Deficiency With Vascular Defect
Vascular Haemophilia	Willebrand Jurgen Thrombopathy
Pseudohaemophilia	Minot-Von Willebrand-Jurgen Disease
Angiohaemophilia	Angiohaemophilia A
Angiohaemophilia B

Cefaclor Allergy

Ceclor Allergy

Cephaclor Allergy

Beta-Lactam Allergy

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Drug Allergy

Allergy Drug

Drug Allergies

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Chlorhexidine Allergy

Cephalosporin Allergy

Nut Allergy

Nut Allergic Reaction	Nut Hypersensitivity
Allergy To Nuts	Allergy Nut

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Fruit Allergy

Allergy To Fruit

Peach Allergy

Prunus Persica Fruit Allergy

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Legume Allergy

Fabaceae Allergy

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Arteriosclerosis

Arteriosclerotic Vascular Disease

Peanut Allergy

Allergy To Peanuts	Peanut Allergic Reaction
Allergies Peanut	Peanut Hypersensitivity

Latex Allergy

Physical Urticaria

Symptomatic Dermographism

Pollen Allergy

Hay Fever

Oxirane Allergy

Ethylene Oxide Allergy

Eto Allergy

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Corneal Dystrophy, Posterior Polymorphous, 2

Posterior Polymorphous Corneal Dystrophy 2	PPCD2
Corneal Dystrophy, Posterior Polymorphous 2	Corneal Dystrophy Polymorphous Posterior, 2
Dystrophy, Corneal, Posterior Polymorphous, Type 2

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146332	Collagen-IN-1		/	Unkown
HY-146333	TRAP-6-IN-1	Inhibitor	/	Unkown
HY-RS02260	CD63 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD63	RGD	RGD:62080
Mus musculus	CD63	MGD	MGI:99529
Macaca mulatta	CD63	VGNC	VGNC:70775
Felis catus	CD63	VGNC	VGNC:83518
Canis familiaris	CD63	VGNC	VGNC:38967
Macaca fascicularis	CD63	NCBI	NCBI:102132387
Susscrofa domestica	CD63	NCBI
Others	CD63	NCBI