2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. TRAP-6-IN-1

TRAP-6-IN-1 (Compound 8) is a dual collagen and TRAP-6 inhibitor with IC50 values of 17.12 µM and 11.88 µM against collagen and TRAP-6, respectively. TRAP-6-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner.

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TRAP-6-IN-1 Chemical Structure

TRAP-6-IN-1 Chemical Structure

CAS No. : 2068737-10-8

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TRAP-6-IN-1 Related Antibodies

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Description

TRAP-6-IN-1 (Compound 8) is a dual collagen and TRAP-6 inhibitor with IC50 values of 17.12 µM and 11.88 µM against collagen and TRAP-6, respectively. TRAP-6-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner[1].

IC50 & Target

IC50: 11.88 µM (TRAP-6), 17.12 µM (collagen)[1]
Cellular Effect
Cell Line Type Value Description References
Platelet IC50
11.88 μM
Compound: 8
Inhibition of TRAP6-induced platelet aggregation in human platelet preincubated for 5 mins followed by TRAP6-stimulation and measured after 6 mins by lumi-aggregometric method
Inhibition of TRAP6-induced platelet aggregation in human platelet preincubated for 5 mins followed by TRAP6-stimulation and measured after 6 mins by lumi-aggregometric method
[PMID: 32155530]
Platelet IC50
17.12 μM
Compound: 8
Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by collagen-stimulation and measured after 6 mins by lumi-aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by collagen-stimulation and measured after 6 mins by lumi-aggregometric method
[PMID: 32155530]
Molecular Weight

284.35

Formula

C18H20O3
CAS No.
SMILES

CCC1(CC)C=CC2=O[H]OC3=C2C1=C(C4=C3CC=CC4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRAP-6-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRAP-6-IN-12068737-10-8Protease Activated Receptor (PAR)Thrombin receptorsP-selectinglycoprotein IIb/IIIaCD63adenosine triphosphateplatelet aggregationInhibitorinhibitorinhibit

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