SDC3 - syndecan 3 Gene

Homo sapiens

Also known as SDCN; SYND3

Gene ID: 9672 | Gene type: protein coding

About SDC3

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:30,869,466-30,909,735 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 64.6), spleen (RPKM 56.5) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin Cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]

SDC3 Products(1)

mRNA	Protein	Name
NM_014654.4	NP_055469.3	syndecan-3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18093920	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18093920	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDC3 Protein Structure

Syndecan

0
100
200
300
400
442 a.a.

Protein Preferred Names

Protein Names

syndecan-3

N-syndecan

SDC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SDC3	O75056	SDC2	Homo sapiens	P34741	Comigration in Gel	18093920
Intra	SDC3	O75056	SDC4	Homo sapiens	P31431	Comigration in Gel	18093920
Intra	SDC3	O75056	RPS4Y1	Homo sapiens	P22090	Anti Tag CoIP	33961781
Intra	SDC3	O75056	SDC3	Homo sapiens	O75056	Comigration in Gel	18093920
Intra	SDC3	O75056	SDC3	Homo sapiens	O75056	ToxCat	18093920
Intra	SDC3	O75056	MYZAP	Homo sapiens	P0CAP1	Anti Tag CoIP	33961781
Intra	SDC3	O75056	KRTAP5-9	Homo sapiens	P26371	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SDC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73624	Syndecan-3 Protein, Human (HEK293, His)	ABM82826 (M1-K311)	≥95%

Related Diseases

Diseases

Alias

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Alcohol-Induced Mental Disorder

Psychoses, Alcoholic

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12581	SDC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SDC3	MGD	MGI:1349163
Macaca mulatta	SDC3	VGNC	VGNC:76999
Bos taurus	SDC3	VGNC	VGNC:34380
Canis familiaris	SDC3	VGNC	VGNC:45943
Felis catus	SDC3	VGNC	VGNC:64945
Rattus norvegicus	SDC3	RGD	RGD:621486
Others	SDC3	NCBI

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