SDC2 - syndecan 2 Gene

Homo sapiens

Also known as HSPG; CD362; HSPG1; SYND2

Gene ID: 6383 | Gene type: protein coding

About SDC2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:96,493,813-96,611,790 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 143.2), liver (RPKM 70.5) and 19 other tissues.

Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

SDC2 Products(1)

mRNA	Protein	Name
NM_002998.4	NP_002989.2	syndecan-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	18256285	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18093920	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9660868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDC2 Protein Structure

Syndecan

0
100
201 a.a.

Protein Preferred Names

Protein Names

syndecan-2

cell surface-associated heparan sulfate proteoglycan 1

SDC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SDC2	P34741	ESRP1	Homo sapiens	Q6NXG1	Y2H Array	32814053
Intra	SDC2	P34741	ESRP1	Homo sapiens	Q6NXG1	Y2H Pooling	32814053
Intra	SDC2	P34741	ESRP1	Homo sapiens	Q6NXG1	Validated Y2H	32814053
Intra	SDC2	P34741	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	SDC2	P34741	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	SDC2	P34741	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	SDC2	P34741	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	SDC2	P34741	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	SDC2	P34741	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	SDC2	P34741	NF1	Homo sapiens	P21359	Y2H	11356864
Intra	SDC2	P34741	SDC1	Homo sapiens	P18827	Anti Tag CoIP	33961781
Intra	SDC2	P34741	SDC1	Homo sapiens	P18827	Comigration in Gel	18093920
Intra	SDC2	P34741	SDC2	Homo sapiens	P34741	Comigration in Gel	18093920
Intra	SDC2	P34741	SDC4	Homo sapiens	P31431	Anti Tag CoIP	33961781
Intra	SDC2	P34741	ccsb_13186	Homo sapiens	EBI-25834291	Validated Y2H	32814053
Intra	SDC2	P34741	SDC2	Homo sapiens	P34741	Y2H	21988832
Intra	SDC2	P34741	SDC4	Homo sapiens	P31431	Comigration in Gel	18093920
Intra	SDC2	P34741	SDC2	Homo sapiens	P34741	ToxCat	18093920
Intra	SDC2	P34741	ccsb_13186	Homo sapiens	EBI-25834291	Y2H Array	32814053
Intra	SDC2	P34741	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
Intra	SDC2	P34741	ccsb_13186	Homo sapiens	EBI-25834291	Y2H Pooling	32814053
Intra	SDC2	P34741	TOM1	Homo sapiens	O60784-2	Validated Y2H	32814053
Intra	SDC2	P34741	TOM1	Homo sapiens	O60784-2	Y2H Pooling	32814053
Intra	SDC2	P34741	TOM1	Homo sapiens	O60784-2	Y2H Array	32814053
Intra	SDC2	P34741	NBL1	Homo sapiens	P41271-2	Y2H Array	32814053
Intra	SDC2	P34741	NBL1	Homo sapiens	P41271-2	Validated Y2H	32814053
Intra	SDC2	P34741	NBL1	Homo sapiens	P41271-2	Y2H Pooling	32814053
Intra	SDC2	P34741	MAPK8IP2	Homo sapiens	Q13387-4	Validated Y2H	32814053
Intra	SDC2	P34741	MAPK8IP2	Homo sapiens	Q13387-4	Y2H Array	32814053
Intra	SDC2	P34741	MAPK8IP2	Homo sapiens	Q13387-4	Y2H Pooling	32814053
Intra	SDC2	P34741	SDC3	Homo sapiens	O75056	Comigration in Gel	18093920
Intra	SDC2	P34741	GRN	Homo sapiens	P28799-2	Y2H Array	32814053
Intra	SDC2	P34741	GRN	Homo sapiens	P28799-2	Validated Y2H	32814053
Intra	SDC2	P34741	GRN	Homo sapiens	P28799-2	Y2H Pooling	32814053
Intra	SDC2	P34741	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	SDC2	P34741	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	SDC2	P34741	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	SDC2	P34741	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SDC2	P34741	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SDC2	P34741	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SDC2	P34741	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SDC2	P34741	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SDC2	P34741	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SDC2	P34741	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	SDC2	P34741	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	SDC2	P34741	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	SDC2	P34741	PIK3R1	Homo sapiens	P27986-2	Validated Y2H	32814053
Intra	SDC2	P34741	PIK3R1	Homo sapiens	P27986-2	Y2H Array	32814053
Intra	SDC2	P34741	PIK3R1	Homo sapiens	P27986-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SDC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70995	Syndecan-2 Protein, Human (HEK293, His)	AAH49836.1 (E19-E144)	≥95%

Related Diseases

Diseases

Alias

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12580	SDC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SDC2	VGNC	VGNC:54120
Mus musculus	SDC2	MGD	MGI:1349165
Macaca mulatta	SDC2	VGNC	VGNC:76998
Felis catus	SDC2	VGNC	VGNC:64944
Bos taurus	SDC2	VGNC	VGNC:34379
Rattus norvegicus	SDC2	RGD	RGD:3649
Others	SDC2	NCBI

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