TGS1 - trimethylguanosine synthase 1 Gene

Homo sapiens

Also known as PIMT; PIPMT; NCOA6IP

Gene ID: 96764 | Gene type: protein coding

About TGS1

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:55,773,446-55,826,445 (from NCBI)

This gene has 3 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in lymph node (RPKM 6.7), appendix (RPKM 5.1) and 25 other tissues.

Summary

Enables RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TGS1 Products(3)

mRNA	Protein	Name
NM_001317902.2	NP_001304831.1	trimethylguanosine synthase isoform 2
NM_001363184.2	NP_001350113.1	trimethylguanosine synthase isoform 3
NM_024831.8	NP_079107.6	trimethylguanosine synthase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA cap trimethylguanosine synthase activity	IDA IDA: Inferred from direct assay	16687569	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21522132	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 7-methylguanosine cap hypermethylation	IDA IDA: Inferred from direct assay	16687569	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12943661	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12943661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGS1 Protein Structure

Methyltransf_15

0
200
400
600
800
853 a.a.

Protein Preferred Names

Protein Names

trimethylguanosine synthase

CLL-associated antigen KW-2

TGS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TGS1	Q96RS0	NOP58	Homo sapiens	Q9Y2X3	Anti Tag CoIP	21522132
Intra	TGS1	Q96RS0	NOP58	Homo sapiens	Q9Y2X3	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TGS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71608	TGS1 Protein, Human (His-SUMO)	Q96RS0 (713M-853T)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14466	TGS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TGS1	VGNC	VGNC:35815
Felis catus	TGS1	VGNC	VGNC:66146
Macaca mulatta	TGS1	VGNC	VGNC:78404
Canis familiaris	TGS1	VGNC	VGNC:47321
Rattus norvegicus	TGS1	RGD	RGD:1309953
Mus musculus	TGS1	MGD	MGI:2151797
Others	TGS1	NCBI

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