2. Gene
  3. NOP58 - NOP58 ribonucleoprotein Gene

NOP58 - NOP58 ribonucleoprotein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NOP5; HSPC120; NOP5/NOP58

Gene ID: 51602 | Gene type: protein coding

About NOP58

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,265,763-202,303,661 (from NCBI)

This gene has 10 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 29.6), lymph node (RPKM 29.1) and 25 other tissues.

Summary

The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

NOP58 Products(1)

mRNA Protein Name
NM_015934.5 NP_057018.1 nucleolar protein 58
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
17636026 GOA
enables TFIID-class transcription factor complex binding IPI
IPI: Inferred from physical interaction
17636026 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17636026 GOA
enables snoRNA binding IDA
IDA: Inferred from direct assay
17636026 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
involved in snoRNA localization IMP
IMP: Inferred from mutant phenotype
17636026 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Cajal body IDA
IDA: Inferred from direct assay
16687569 GOA
part of box C/D methylation guide snoRNP complex IDA
IDA: Inferred from direct assay
33367824 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16687569 GOA
part of pre-snoRNP complex IDA
IDA: Inferred from direct assay
17636026 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
part of sno(s)RNA-containing ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17636026 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOP58 Protein Structure

NOP5NT

NOP5NT: NOP5NT (NUC127) domain (1 - 66)

(161 - 213)

Nop

Nop: snoRNA binding domain, fibrillarin (253 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

nucleolar protein 58

NOP58 ribonucleoprotein homolog

NOP58 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NOP58 Q9Y2X3 NUFIP1 Homo sapiens Q9UHK0
Anti Bait CoIP
17636026
Intra
NOP58 Q9Y2X3 NUFIP1 Homo sapiens Q9UHK0
Anti Tag CoIP
35271311
Intra
NOP58 Q9Y2X3 NOPCHAP1 Homo sapiens Q8N5I9
Anti Tag CoIP
35271311
Intra
NOP58 Q9Y2X3 NOPCHAP1 Homo sapiens Q8N5I9
Anti Tag CoIP
33961781
Intra
NOP58 Q9Y2X3 SNU13 Homo sapiens P55769
Crosslink
30021884
Intra
NOP58 Q9Y2X3 SNU13 Homo sapiens P55769
Anti Tag CoIP
35271311
Intra
NOP58 Q9Y2X3 TGS1 Homo sapiens Q96RS0
Pull Down
21522132
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09431 NOP58 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NOP58 RGD RGD:620484
Canis familiaris NOP58 VGNC VGNC:43892
Bos taurus NOP58 VGNC VGNC:32170
Felis catus NOP58 VGNC VGNC:63859
Macaca mulatta NOP58 VGNC VGNC:75284
Mus musculus NOP58 MGD MGI:1933184