PPP6R2 - protein phosphatase 6 regulatory subunit 2 Gene

Homo sapiens

Also known as PP6R2; SAPS2; SAP190; KIAA0685

Gene ID: 9701 | Gene type: protein coding

About PPP6R2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,330,774-50,445,090 (from NCBI)

This gene has 9 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 24.1), brain (RPKM 12.1) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop Phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]

PPP6R2 Products(13)

mRNA	Protein	Name
NM_001242898.2	NP_001229827.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1
NM_001242899.2	NP_001229828.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2
NM_001242900.2	NP_001229829.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 4
NM_001351641.2	NP_001338570.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 5
NM_001351642.2	NP_001338571.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 6
NM_001351643.2	NP_001338572.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1
NM_001351644.2	NP_001338573.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 7
NM_001351645.2	NP_001338574.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3
NM_001351646.2	NP_001338575.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 8
NM_001351647.2	NP_001338576.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 9
NM_001351648.2	NP_001338577.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 10
NM_001365836.1	NP_001352765.1	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 11
NM_014678.5	NP_055493.2	serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP6R2 Protein Structure

SAPS

0
200
400
600
800
966 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 6 regulatory subunit 2

SAPS domain family, member 2

PPP6R2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP6R2	O75170	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	33961781
Intra	PPP6R2	O75170	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	24255178
Intra	PPP6R2	O75170	ANKRD28	Homo sapiens	O15084	BioID	24255178
Intra	PPP6R2	O75170	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	18186651
Intra	PPP6R2	O75170	PPP6C	Homo sapiens	O00743	BioID	24255178
Intra	PPP6R2	O75170	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	24255178

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease, Type 4b3

Charcot-Marie-Tooth Disease Type 4b3	CMT4B3
Charcot-Marie-Tooth Disease With Focally Folded Myelin	Charcot-Marie-Tooth Disease 4b3
Charcot-Marie-Tooth Neuropathy Type 4b3

Acute Cor Pulmonale

Acute Pulmonary Heart Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11035	PPP6R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP6R2	VGNC	VGNC:33274
Macaca mulatta	PPP6R2	VGNC	VGNC:76288
Rattus norvegicus	PPP6R2	RGD	RGD:1563990
Mus musculus	PPP6R2	MGD	MGI:1918724
Felis catus	PPP6R2	VGNC	VGNC:64333
Canis familiaris	PPP6R2	VGNC	VGNC:44926

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