2. Gene
  3. PPP6C - protein phosphatase 6 catalytic subunit Gene

PPP6C - protein phosphatase 6 catalytic subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP6; PP6C

Gene ID: 5537 | Gene type: protein coding

About PPP6C

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,146,573-125,189,803 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues, 12 paralogues and is associated with 71 phenotypes. Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues.

Summary

This gene encodes the catalytic subunit of protein Phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

PPP6C Products(3)

mRNA Protein Name
NM_001123355.2 NP_001116827.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform a
NM_001123369.2 NP_001116841.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform c
NM_002721.5 NP_002712.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9647778 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
32474700 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: Inferred from direct assay
32474700 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP6C Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (47 - 238)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 6 catalytic subunit

serine/threonine protein phosphatase catalytic subunit

PPP6C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP6C O00743 TIPRL Homo sapiens O75663
Anti Tag CoIP
16085932
Intra
PPP6C O00743 TIPRL Homo sapiens O75663
Anti Tag CoIP
24255178
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Y2H Prey Pooling
32296183
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Anti Tag CoIP
33961781
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Y2H
9647778
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Validated Y2H
32296183
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Y2H Array
32296183
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Anti Tag CoIP
24255178
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Pull Down
28330616
Intra
PPP6C O00743 IGBP1 Homo sapiens P78318
Anti Tag CoIP
9647778
Intra
PPP6C O00743 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra
PPP6C O00743 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
PPP6C O00743 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
PPP6C O00743 PPP6R3 Homo sapiens Q5H9R7
Pull Down
28330616
Intra
PPP6C O00743 PPP6R3 Homo sapiens Q5H9R7
Anti Tag CoIP
21187329
Intra
PPP6C O00743 PPP6R3 Homo sapiens Q5H9R7
Anti Tag CoIP
33961781
Intra
PPP6C O00743 PPP6R3 Homo sapiens Q5H9R7
Anti Tag CoIP
24255178
Intra
PPP6C O00743 MAP3K7 Homo sapiens O43318
Anti Bait CoIP
17079228
Intra
PPP6C O00743 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
33961781
Intra
PPP6C O00743 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
21187329
Intra
PPP6C O00743 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
24255178
Intra
PPP6C O00743 ANKRD28 Homo sapiens O15084
Pull Down
28330616
Intra
PPP6C O00743 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
18186651
Intra
PPP6C O00743 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
18186651
Intra
PPP6C O00743 PPP6R2 Homo sapiens O75170
Pull Down
28330616
Intra
PPP6C O00743 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
16769727
Intra
PPP6C O00743 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
24255178
Intra
PPP6C O00743 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
21187329
Intra
PPP6C O00743 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
33961781
Intra
PPP6C O00743 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
18186651
Intra
PPP6C O00743 PPP6R1 Homo sapiens Q9UPN7
Pull Down
28330616
Intra
PPP6C O00743 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
16769727
Intra
PPP6C O00743 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
24255178
Intra
PPP6C O00743 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
21187329
Intra
PPP6C O00743 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Melanoma

Cutaneous Melanoma

Malignant Ear Melanoma

Malignant Lip Melanoma

Malignant Lower Limb Melanoma

Malignant Melanoma Of Ear And/Or External Auricular Canal

Malignant Melanoma Of Skin Of Lower Limb

Malignant Melanoma Of Skin Of Trunk Except Scrotum

Malignant Melanoma Of Skin Of Upper Limb

Malignant Neck Melanoma

Malignant Scalp Melanoma

Malignant Trunk Melanoma

Malignant Upper Limb Melanoma

Melanoma, Cutaneous Malignant

Melanoma

Malignant Melanoma Of Skin

Melanoma Nos

Malignant Mole, Meaning Melanoma Of Unspecified Site

Melanoma Of Unspecified Site

Cutaneous Malignant Melanoma

Mm - [Malignant Melanoma]
Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung

Squamous Cell Lung Carcinoma

Epidermoid Cell Carcinoma Of The Lung

Squamous Cell Lung Cancer
Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation

Pineal Parenchymal Tumors Of Intermediate Differentiation

Pptid
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11033 PPP6C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP6C VGNC VGNC:102969
Mus musculus PPP6C MGD MGI:1915107
Canis familiaris PPP6C VGNC VGNC:49946
Macaca mulatta PPP6C VGNC VGNC:101481
Bos taurus PPP6C VGNC VGNC:33273
Rattus norvegicus PPP6C RGD RGD:708460