2. Gene
  3. TBKBP1 - TBK1 binding protein 1 Gene

TBKBP1 - TBK1 binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SINTBAD; ProSAPiP2

Gene ID: 9755 | Gene type: protein coding

About TBKBP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,694,063-47,712,063 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 4.8), fat (RPKM 4.5) and 25 other tissues.

Summary

TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

TBKBP1 Products(3)

mRNA Protein Name
NM_001394755.1 NP_001381684.1 TANK-binding kinase 1-binding protein 1
NM_001394756.1 NP_001381685.1 TANK-binding kinase 1-binding protein 1
NM_014726.2 NP_055541.1 TANK-binding kinase 1-binding protein 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14743216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBKBP1 Protein Structure

TBD

TBD: TBD domain (286 - 341)

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  • 615 a.a.
Protein Preferred Names Protein Names

TANK-binding kinase 1-binding protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14260 TBKBP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TBKBP1 RGD RGD:631328
Felis catus TBKBP1 VGNC VGNC:65998
Canis familiaris TBKBP1 VGNC VGNC:47161
Macaca mulatta TBKBP1 VGNC VGNC:78241
Bos taurus TBKBP1 VGNC VGNC:35657
Mus musculus TBKBP1 MGD MGI:1920424