TBKBP1 - TBK1 binding protein 1 Gene

Homo sapiens

Also known as SINTBAD; ProSAPiP2

Gene ID: 9755 | Gene type: protein coding

About TBKBP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,694,063-47,712,063 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 4.8), fat (RPKM 4.5) and 25 other tissues.

Summary

TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

TBKBP1 Products(3)

mRNA	Protein	Name
NM_001394755.1	NP_001381684.1	TANK-binding kinase 1-binding protein 1
NM_001394756.1	NP_001381685.1	TANK-binding kinase 1-binding protein 1
NM_014726.2	NP_055541.1	TANK-binding kinase 1-binding protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBKBP1 Protein Structure

TBD

0
100
200
300
400
500
615 a.a.

Protein Preferred Names

Protein Names

TANK-binding kinase 1-binding protein 1

TBKBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TBKBP1	A7MCY6	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	21903422
Intra	TBKBP1	A7MCY6	IKBKE	Homo sapiens	Q14164	Anti Bait CoIP	17568778
Intra	TBKBP1	A7MCY6	IKBKE	Homo sapiens	Q14164	Lumier	21931555
Intra	TBKBP1	A7MCY6	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	21903422
Intra	TBKBP1	A7MCY6	TBK1	Homo sapiens	Q9UHD2	Lumier	21931555
Intra	TBKBP1	A7MCY6	TBK1	Homo sapiens	Q9UHD2	TAP	14743216
Intra	TBKBP1	A7MCY6	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	17568778
Intra	TBKBP1	A7MCY6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	17568778
Intra	TBKBP1	A7MCY6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	TBKBP1	A7MCY6	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21903422
Intra	TBKBP1	A7MCY6	APBA3	Homo sapiens	O96018	Anti Tag CoIP	21903422
Cross	TBKBP1	A7MCY6	OPG029	vaccinia virus	P17362	Anti Tag CoIP	21931555

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14260	TBKBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TBKBP1	RGD	RGD:631328
Felis catus	TBKBP1	VGNC	VGNC:65998
Canis familiaris	TBKBP1	VGNC	VGNC:47161
Macaca mulatta	TBKBP1	VGNC	VGNC:78241
Bos taurus	TBKBP1	VGNC	VGNC:35657
Mus musculus	TBKBP1	MGD	MGI:1920424

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