2. Gene
  3. RB1CC1 - RB1 inducible coiled-coil 1 Gene

RB1CC1 - RB1 inducible coiled-coil 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CC1; ATG17; FIP200; PPP1R131

Gene ID: 9821 | Gene type: protein coding

About RB1CC1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,622,458-52,714,435 (from NCBI)

This gene has 10 transcripts (splice variants), 223 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 14.7), brain (RPKM 11.4) and 25 other tissues.

Summary

The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, Apoptosis, Autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in Cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

RB1CC1 Products(2)

mRNA Protein Name
NM_001083617.2 NP_001077086.1 RB1-inducible coiled-coil protein 1 isoform 2
NM_014781.5 NP_055596.3 RB1-inducible coiled-coil protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19211835 GOA
enables protein kinase binding IDA
IDA: Inferred from direct assay
19211835 GOA
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
23392225 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
19225151 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21795849 GOA
involved in regulation of protein lipidation IDA
IDA: Inferred from direct assay
19225151 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Atg1/ULK1 kinase complex IPI
IPI: Inferred from physical interaction
19211835 GOA
located in lysosome IDA
IDA: Inferred from direct assay
28561066 GOA
is active in phagophore assembly site IDA
IDA: Inferred from direct assay
28561066 GOA
located in phagophore assembly site IDA
IDA: Inferred from direct assay
19597335 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RB1CC1 Protein Structure

ATG11

ATG11: Autophagy-related protein 11 (1478 - 1588)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1594 a.a.
Protein Preferred Names Protein Names

RB1-inducible coiled-coil protein 1

200 kDa FAK family kinase-interacting protein

RB1CC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RB1CC1 Q8TDY2 ATG5 Homo sapiens Q9H1Y0
Crosslink
23392225
Intra
RB1CC1 Q8TDY2 ATG5 Homo sapiens Q9H1Y0
Anti Tag CoIP
23262492
Cross
RB1CC1 Q8TDY2 Atg16l1 Mus musculus Q8C0J2-3
Anti Tag CoIP
23262492
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-1
Pull Down
27334615
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-1
PLA
27334615
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-1
Anti Tag CoIP
27334615
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-2
Anti Tag CoIP
27334615
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-2
IF
27334615
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-2
Pull Down
27334615
Intra
RB1CC1 Q8TDY2 C9orf72 Homo sapiens Q96LT7-2
PLA
27334615
Intra
RB1CC1 Q8TDY2 ATG13 Homo sapiens O75143
Anti Tag CoIP
20562859
Intra
RB1CC1 Q8TDY2 ATG13 Homo sapiens O75143
Crosslink
23392225
Intra
RB1CC1 Q8TDY2 ATG101 Homo sapiens Q9BSB4
Anti Tag CoIP
20562859
Intra
RB1CC1 Q8TDY2 ATG101 Homo sapiens Q9BSB4
BioID
34524948
Intra
RB1CC1 Q8TDY2 ATG101 Homo sapiens Q9BSB4
Crosslink
23392225
Intra
RB1CC1 Q8TDY2 ATG101 Homo sapiens Q9BSB4
Anti Tag CoIP
19597335
Intra
RB1CC1 Q8TDY2 TBKBP1 Homo sapiens A7MCY6
Anti Tag CoIP
21903422
Intra
RB1CC1 Q8TDY2 ATG16L1 Homo sapiens Q676U5
Anti Tag CoIP
20562859
Intra
RB1CC1 Q8TDY2 ATG16L1 Homo sapiens Q676U5
Crosslink
23392225
Intra
RB1CC1 Q8TDY2 ATG16L1 Homo sapiens Q676U5
Anti Tag CoIP
23262492
Intra
RB1CC1 Q8TDY2 ULK1 Homo sapiens O75385
BioID
34524948
Intra
RB1CC1 Q8TDY2 ULK1 Homo sapiens O75385
Crosslink
23392225
Intra
RB1CC1 Q8TDY2 ULK1 Homo sapiens O75385
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Vulvar Leiomyoma
Vulvar Benign Neoplasm
Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency

VICIS

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

Dionisi Vici Sabetta Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

Dionisi-Vici-Sabetta-Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Neurodegeneration With Brain Iron Accumulation 5

NBIA5

Beta-Propeller Protein-Associated Neurodegeneration

Bpan

Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood

Senda

Neurodegeneration With Brain Iron Accumulation Type 5

Neurodegeneration With Brain Iron Accululation 5

Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood

Neurodegeneration, With Brain Iron Accululation, Type 5
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11714 RB1CC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RB1CC1 VGNC VGNC:64514
Bos taurus RB1CC1 VGNC VGNC:33769
Macaca mulatta RB1CC1 VGNC VGNC:76483
Canis familiaris RB1CC1 VGNC VGNC:45390
Mus musculus RB1CC1 MGD MGI:1341850
Rattus norvegicus RB1CC1 RGD RGD:1309346