JADE3 - jade family PHD finger 3 Gene

Homo sapiens

Also known as PHF16; JADE-3

Gene ID: 9767 | Gene type: protein coding

About JADE3

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:46,912,301-47,061,242 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 8 paralogues. Broad expression in testis (RPKM 8.9), placenta (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

JADE3 Products(2)

mRNA	Protein	Name
NM_001077445.3	NP_001070913.1	protein Jade-3
NM_014735.5	NP_055550.1	protein Jade-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA replication	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16387653	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16387653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JADE3 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

0
200
400
600
823 a.a.

Protein Preferred Names

Protein Names

protein Jade-3

PHD finger protein 16

JADE3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	JADE3	Q92613	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956
Intra	JADE3	Q92613	MAGEA11	Homo sapiens	P43364-2	Y2H Prey Pooling	25416956
Intra	JADE3	Q92613	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	JADE3	Q92613	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	JADE3	Q92613	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	JADE3	Q92613	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	JADE3	Q92613	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	JADE3	Q92613	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	JADE3	Q92613	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	JADE3	Q92613	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07011	JADE3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	JADE3	VGNC	VGNC:62997
Macaca mulatta	JADE3	VGNC	VGNC:73640
Rattus norvegicus	JADE3	RGD	RGD:1563945
Canis familiaris	JADE3	VGNC	VGNC:42171
Bos taurus	JADE3	VGNC	VGNC:30360
Mus musculus	JADE3	MGD	MGI:2148019

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