RNF144A - ring finger protein 144A Gene

Homo sapiens

Also known as UIP4; hUIP4; RNF144; UBCE7IP4

Gene ID: 9781 | Gene type: protein coding

About RNF144A

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:6,917,412-7,076,367 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 4.0), endometrium (RPKM 3.6) and 24 other tissues.

Summary

This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating Enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]

RNF144A Products(7)

mRNA	Protein	Name
NM_001349181.2	NP_001336110.1	E3 ubiquitin-protein ligase RNF144A isoform 1
NM_001349182.2	NP_001336111.1	E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349183.2	NP_001336112.1	E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349184.2	NP_001336113.1	E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349185.2	NP_001336114.1	E3 ubiquitin-protein ligase RNF144A isoform 3
NM_001349186.2	NP_001336115.1	E3 ubiquitin-protein ligase RNF144A isoform 4
NM_014746.6	NP_055561.2	E3 ubiquitin-protein ligase RNF144A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA
enables ubiquitin protein ligase activity	EXP EXP: Inferred from Experiment	24979766	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	37955227	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	37955227	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	37955227	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10942595	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	37955227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF144A Protein Structure

IBR

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF144A

UbcM4-interacting protein 4

RNF144A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF144A	P50876	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	RNF144A	P50876	PAQR6	Homo sapiens	Q6TCH4	Validated Y2H	32296183
Intra	RNF144A	P50876	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	RNF144A	P50876	RFT1	Homo sapiens	Q96AA3	Validated Y2H	32296183
Intra	RNF144A	P50876	RFT1	Homo sapiens	Q96AA3	Y2H Array	32296183
Intra	RNF144A	P50876	CKAP4	Homo sapiens	Q07065	Anti Tag CoIP	33961781
Intra	RNF144A	P50876	CKAP4	Homo sapiens	Q07065	Anti Tag CoIP	28514442
Intra	RNF144A	P50876	UBE2L3	Homo sapiens	P68036	Y2H Array	19549727
Intra	RNF144A	P50876	UBE2L3	Homo sapiens	P68036	Validated Y2H	32296183
Intra	RNF144A	P50876	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	RNF144A	P50876	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12053	RNF144A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RNF144A	VGNC	VGNC:45635
Felis catus	RNF144A	VGNC	VGNC:64673
Rattus norvegicus	RNF144A	RGD	RGD:1561737
Bos taurus	RNF144A	VGNC	VGNC:34026
Macaca mulatta	RNF144A	VGNC	VGNC:106212
Mus musculus	RNF144A	MGD	MGI:1344401

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