2. Gene
  3. RNF144A - ring finger protein 144A Gene

RNF144A - ring finger protein 144A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UIP4; hUIP4; RNF144; UBCE7IP4

Gene ID: 9781 | Gene type: protein coding

About RNF144A

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:6,917,412-7,076,367 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 4.0), endometrium (RPKM 3.6) and 24 other tissues.

Summary

This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating Enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]

RNF144A Products(7)

mRNA Protein Name
NM_001349181.2 NP_001336110.1 E3 ubiquitin-protein ligase RNF144A isoform 1
NM_001349182.2 NP_001336111.1 E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349183.2 NP_001336112.1 E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349184.2 NP_001336113.1 E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349185.2 NP_001336114.1 E3 ubiquitin-protein ligase RNF144A isoform 3
NM_001349186.2 NP_001336115.1 E3 ubiquitin-protein ligase RNF144A isoform 4
NM_014746.6 NP_055561.2 E3 ubiquitin-protein ligase RNF144A isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19549727 GOA
enables ubiquitin protein ligase activity EXP
EXP: Inferred from Experiment
24979766 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
37955227 GOA
Biological Process GO Annotation Evidence Reference Source
involved in pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
37955227 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
37955227 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10942595 GOA
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
37955227 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF144A Protein Structure

IBR

IBR: IBR domain, a half RING-finger domain (91 - 156)

IBR

IBR: IBR domain, a half RING-finger domain (177 - 217)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF144A

UbcM4-interacting protein 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12053 RNF144A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RNF144A VGNC VGNC:45635
Felis catus RNF144A VGNC VGNC:64673
Rattus norvegicus RNF144A RGD RGD:1561737
Bos taurus RNF144A VGNC VGNC:34026
Macaca mulatta RNF144A VGNC VGNC:106212
Mus musculus RNF144A MGD MGI:1344401