IST1 - IST1 factor associated with ESCRT-III Gene

Homo sapiens

Also known as OLC1; CHMP8

Gene ID: 9798 | Gene type: protein coding

About IST1

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,894,408-71,931,199 (from NCBI)

This gene has 27 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in bone marrow (RPKM 49.3), gall bladder (RPKM 37.7) and 25 other tissues.

Summary

This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

IST1 Products(6)

mRNA	Protein	Name
NM_001270975.2	NP_001257904.1	IST1 homolog isoform a
NM_001270976.1	NP_001257905.1	IST1 homolog isoform c
NM_001270977.2	NP_001257906.1	IST1 homolog isoform d
NM_001270978.2	NP_001257907.1	IST1 homolog isoform e
NM_001270979.1	NP_001257908.1	IST1 homolog isoform e
NM_014761.4	NP_055576.2	IST1 homolog isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MIT domain binding	IPI IPI: Inferred from physical interaction	19129479	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19525971	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	20719964	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	19129479	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in abscission	IDA IDA: Inferred from direct assay	19129479	GOA
involved in abscission	IMP IMP: Inferred from mutant phenotype	19525971	GOA
involved in cell division	IMP IMP: Inferred from mutant phenotype	19129479	GOA
involved in cytoskeleton-dependent cytokinesis	IMP IMP: Inferred from mutant phenotype	19525971	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23015756	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	20849418	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	20719964	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Flemming body	IDA IDA: Inferred from direct assay	19129479	GOA
located in centrosome	IDA IDA: Inferred from direct assay	19129479	GOA
located in chromatin	IDA IDA: Inferred from direct assay	28242692	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19129480	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	10942595	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in midbody	IDA IDA: Inferred from direct assay	19129479	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IST1 Protein Structure

Ist1

0
100
200
300
379 a.a.

Protein Preferred Names

Protein Names

IST1 homolog

IST1, ESCRT-III associated factor

IST1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IST1	P53990	CAPN7	Homo sapiens	Q9Y6W3	Anti Tag CoIP	20849418
Intra	IST1	P53990	CAPN7	Homo sapiens	Q9Y6W3	Pull Down	20849418
Intra	IST1	P53990	APEH	Homo sapiens	P13798	Y2H Prey Pooling	25416956
Intra	IST1	P53990	APEH	Homo sapiens	P13798	Validated Y2H	25416956
Intra	IST1	P53990	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	IST1	P53990	VPS9D1	Homo sapiens	Q9Y2B5	Anti Tag CoIP	35271311
Intra	IST1	P53990	ATXN1	Homo sapiens	P54253	Y2H Array	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gastric Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Stomach

Squamous Cell Carcinoma Of The Stomach

Spastic Paraplegia 20, Autosomal Recessive

Troyer Syndrome	SPG20
Spastic Paraparesis, Childhood-Onset, With Distal Muscle Wasting	Spastic Paraplegia, Autosomal Recessive, Troyer Type
Autosomal Recessive Spastic Paraplegia Type 20	Autosomal Recessive Hereditary Spastic Paraplegia
Spastic Paraplegia 20	Cross-Mckusick Syndrome
Autosomal Recessive Spastic Paraplegia 20	Autosomal Recessive Spastic Paraplegia Troyer Type
Childhood-Onset Spastic Paraparesis With Distal Muscle Wasting	Hereditary Spastic Paraplegia 20
Spastic Paraplegia Type 20	Hereditary Spastic Paraplegia
Childhood-Onset Spastic Paraparesis-Distal Muscle Wasting Syndrome	Spastic Paraparesis Childhood-Onset With Distal Muscle Wasting
Spastic Paraplegia Autosomal Recessive Troyer Type	Trs
Spastic Paraplegia Hereditary Autosomal Recessive	Spastic Paraplegia, Hereditary

Spastic Paraplegia 10, Autosomal Dominant

SPG10	Hereditary Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia Type 10	Spastic Paraplegia 10
Spastic Paraplegia 10 With Or Without Peripheral Neuropathy	Autosomal Dominant Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia	Spastic Paraplegia, Autosomal Dominant
Paraplegia, Spastic, Autosomal Dominant, Type 10

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06939	IST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IST1	VGNC	VGNC:73675
Canis familiaris	IST1	VGNC	VGNC:49862
Rattus norvegicus	IST1	RGD	RGD:1307799
Bos taurus	IST1	VGNC	VGNC:30304
Felis catus	IST1	VGNC	VGNC:62980
Mus musculus	IST1	MGD	MGI:1919205
Others	IST1	NCBI

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