CEP350 - centrosomal protein 350 Gene

Homo sapiens

Also known as GM133; CAP350

Gene ID: 9857 | Gene type: protein coding

About CEP350

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:179,954,810-180,114,875 (from NCBI)

This gene has 25 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 13.0), lymph node (RPKM 5.9) and 25 other tissues.

Summary

The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

CEP350 Products(1)

mRNA	Protein	Name
NM_014810.5	NP_055625.4	centrosome-associated protein 350

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25134987	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to centrosome	IDA IDA: Inferred from direct assay	36756949	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in centriole	IDA IDA: Inferred from direct assay	36756949	GOA
located in centriole	IDA IDA: Inferred from direct assay	28625565	GOA
is active in centrosome	IDA IDA: Inferred from direct assay	36756949	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEP350 Protein Structure

CAP_GLY

0
500
1000
1500
2000
2500
3117 a.a.

Protein Preferred Names

Protein Names

centrosome-associated protein 350

centrosomal protein 350kDa

CEP350 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEP350	Q5VT06	CTNNA1	Homo sapiens	P35221	Y2H	25764135
Intra	CEP350	Q5VT06	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	25764135
Intra	CEP350	Q5VT06	CTNNA1	Homo sapiens	P35221	Anti Tag CoIP	25764135

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epidermal Appendage Tumor

Neoplasm Of Skin With Adnexal Differentiation	Neoplasm Of The Skin Appendage
Skin Appendage Tumour

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02513	CEP350 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CEP350	VGNC	VGNC:71084
Felis catus	CEP350	VGNC	VGNC:60773
Bos taurus	CEP350	VGNC	VGNC:27203
Canis familiaris	CEP350	VGNC	VGNC:39127
Mus musculus	CEP350	MGD	MGI:1921331
Rattus norvegicus	CEP350	RGD	RGD:621162

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