LRIG2 - leucine rich repeats and immunoglobulin like domains 2 Gene

Homo sapiens

Also known as LIG2; UFS2; LIG-2

Gene ID: 9860 | Gene type: protein coding

About LRIG2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,073,198-113,132,260 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 2.7), ovary (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

LRIG2 Products(2)

mRNA	Protein	Name
NM_001312686.2	NP_001299615.1	leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2
NM_014813.3	NP_055628.1	leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25353163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRIG2 Protein Structure

LRR_8

LRR_6

LRR_8

LRR_1

Ig_2

I-set

0
200
400
600
800
1000
1065 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeats and immunoglobulin-like domains protein 2

Related Diseases

Diseases

Alias

Urofacial Syndrome 2

UFS2

Urofacial Syndrome 1

Urofacial Syndrome	Ochoa Syndrome
Hydronephrosis With Peculiar Facial Expression	Ufs
Inverted Smile And Occult Neuropathic Bladder	Partial Facial Palsy With Urinary Abnormalities
UFS1	Urofacial Ochoa'S Syndrome
Urofacial Syndrome Type 1	Facial Palsy, Partial, With Urinary Abnormalities
Hydronephrosis-Inverted Smile	Inverted Smile-Neurogenic Bladder
Hydronephrosis-Inverted Smile Syndrome	Inverted Smile-Neurogenic Bladder Syndrome
Partial Facial Palsy Partial With Urinary Abnormalities	Urologic Diseases

Prune Belly Syndrome

Eagle-Barrett Syndrome	Abdominal Muscle Deficiency Syndrome
PBS	Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
Egbrs	Eagle-Barret Syndrome
Urethral Obstruction Sequence	Obrinsky Syndrome
Triad Syndrome	Obrisnksy Syndrome
Euos	Early Urethral Obstruction Sequence
Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction	Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism
Abdomen Muscle Deficiency Syndrome	Abdomen Muscular Deficiency Syndrome
Abdominal Muscular Deficiency Syndrome	Abdominal Muscle Aplasia Syndrome

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids

Corpus Callosum, Agenesis Of, With Abnormal Genitalia

Proud Syndrome	Corpus Callosum Agenesis-Abnormal Genitalia Syndrome
Acc With Abnormal Genitalia	Proud-Levine-Carpenter Syndrome
Microcephaly-Corpus Callosum Agenesis-Abnormal Genitalia Syndrome	Corpus Callosum Agenesis With Abnormal Genitalia
New X-Linked Syndrome With Seizures, Acquired Micrencephaly, And Agenesis Of The Corpus Callosum	Proud Levine Carpenter Syndrome
Acc-Abnormal Genitalia Syndrome	Agenesis Of The Corpus Callosum, With Abnormal Genitalia
ACCAG	Micrencephaly-Corpus Callosum Agenesis-Abnormal Genitalia
Congenital Neurologic Anomalies

Vaginal Cancer

Malignant Neoplasm Of Vagina	Vaginal Neoplasms
Malignant Tumor Of Vagina	Malignant Vaginal Tumor
Neoplasm Of Vagina	Vagina Neoplasm
Vaginal Tumor	Vaginal Carcinoma
Vaginal Malignant Epithelial Tumor	Vaginal Neoplasm
Malignant Vaginal Neoplasm	Vagina Carcinoma
Vaginal Neoplasia	Cancer Of Vagina
Malignant Tumour Of Vagina	Carcinoma Of Vagina
Primary Malignant Neoplasm Of Vagina	Vagina Wall Cancer
Vaginal Wall Cancer

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder	Neurogenic Urinary Bladder Disorder
Neuropathic Bladder	Bladder Neurogenic
Urinary Bladder, Neurogenic	Neurogenic Urinary Bladder

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome	Berdon Syndrome
MMIHS	Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Megacystis, Microcolon, Hypoperistalsis Syndrome	Visceral Myopathy
Mmih Syndrome	Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome
MMIHS1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih
Mmhs

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07788	LRIG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRIG2	RGD	RGD:1309554
Felis catus	LRIG2	VGNC	VGNC:63281
Mus musculus	LRIG2	MGD	MGI:2443718
Macaca mulatta	LRIG2	VGNC	VGNC:74323
Bos taurus	LRIG2	VGNC	VGNC:30983
Canis familiaris	LRIG2	VGNC	VGNC:42768

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