PSMD6 - proteasome 26S subunit, non-ATPase 6 Gene

Homo sapiens

Also known as S10; Rpn7; p42A; p44S10; SGA-113M

Gene ID: 9861 | Gene type: protein coding

About PSMD6

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:64,010,551-64,024,007 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 47.2), bone marrow (RPKM 29.6) and 25 other tissues.

Summary

This gene encodes a member of the Protease subunit S10 family. The encoded protein is a subunit of the 26S Proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

PSMD6 Products(4)

mRNA	Protein	Name
NM_001271779.2	NP_001258708.1	26S proteasome non-ATPase regulatory subunit 6 isoform 1
NM_001271780.2	NP_001258709.1	26S proteasome non-ATPase regulatory subunit 6 isoform 3
NM_001271781.2	NP_001258710.1	26S proteasome non-ATPase regulatory subunit 6 isoform 4
NM_014814.3	NP_055629.1	26S proteasome non-ATPase regulatory subunit 6 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16990800	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD6 Protein Structure

RPN7

PCI

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 6

breast cancer-associated protein SGA-113M

PSMD6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMD6	Q15008	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	PSMD6	Q15008	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	PSMD6	Q15008	CMTM7	Homo sapiens	Q96FZ5	Y2H Prey Pooling	32296183
Intra	PSMD6	Q15008	CMTM7	Homo sapiens	Q96FZ5	Y2H Array	32296183
Intra	PSMD6	Q15008	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	PSMD6	Q15008	PSMD4	Homo sapiens	P55036	Anti Bait CoIP	17353931
Intra	PSMD6	Q15008	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	PSMD6	Q15008	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	PSMD6	Q15008	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11327	PSMD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMD6	VGNC	VGNC:69126
Rattus norvegicus	PSMD6	RGD	RGD:735127
Mus musculus	PSMD6	MGD	MGI:1913663
Canis familiaris	PSMD6	VGNC	VGNC:54345
Bos taurus	PSMD6	VGNC	VGNC:33470
Macaca mulatta	PSMD6	VGNC	VGNC:76454

Name
Email *

	Sorry, but the email address you supplied was invalid.