PSMD4 - proteasome 26S subunit ubiquitin receptor, non-ATPase 4 Gene

Homo sapiens

Also known as AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5

Gene ID: 5710 | Gene type: protein coding

About PSMD4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,254,734-151,267,479 (from NCBI)

This gene has 12 transcripts (splice variants) and 285 orthologues. Ubiquitous expression in testis (RPKM 64.3), placenta (RPKM 46.6) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]

PSMD4 Products(2)

mRNA	Protein	Name
NM_001330692.2	NP_001317621.1	26S proteasome non-ATPase regulatory subunit 4 isoform 1
NM_002810.4	NP_002801.1	26S proteasome non-ATPase regulatory subunit 4 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16990800	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	32157086	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10488153	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD4 Protein Structure

VWA_2

UIM

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 4

26S proteasome regulatory subunit S5A

PSMD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMD4	P55036	UBE3A	Homo sapiens	Q05086-2	Anti Tag CoIP	29426014
Intra	PSMD4	P55036	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	35271311
Cross	PSMD4	P55036	Pax3	Mus musculus	P24610	Pull Down	17662948
Intra	PSMD4	P55036	SCHIP1	Homo sapiens	P0DPB3	TAP	20195357
Intra	PSMD4	P55036	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	PSMD4	P55036	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	PSMD4	P55036	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	PSMD4	P55036	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	PSMD4	P55036	PSMA5	Homo sapiens	P28066	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMA5	Homo sapiens	P28066	GMS	29426014
Intra	PSMD4	P55036	PSMA5	Homo sapiens	P28066	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD13	Homo sapiens	Q9UNM6	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMD13	Homo sapiens	Q9UNM6	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD3	Homo sapiens	O43242	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMD3	Homo sapiens	O43242	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD3	Homo sapiens	O43242	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMD2	Homo sapiens	Q13200	Density Sedimentation	16990800
Intra	PSMD4	P55036	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMD11	Homo sapiens	O00231	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMD11	Homo sapiens	O00231	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMD11	Homo sapiens	O00231	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD1	Homo sapiens	Q99460	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD1	Homo sapiens	Q99460	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMD8	Homo sapiens	P48556	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD8	Homo sapiens	P48556	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	RAD23A	Homo sapiens	P54725	SLC	31467278
Intra	PSMD4	P55036	RAD23A	Homo sapiens	P54725	BRET	29997244
Intra	PSMD4	P55036	RAD23A	Homo sapiens	P54725	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	RAD23B	Homo sapiens	P54727	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	RAD23B	Homo sapiens	P54727	Pull Down	20059542
Intra	PSMD4	P55036	RAD23B	Homo sapiens	P54727	Pull Down	10488153
Intra	PSMD4	P55036	RAD23B	Homo sapiens	P54727	Y2H	10488153
Intra	PSMD4	P55036	RAD23A	Homo sapiens	P54725	BRET	37398436
Intra	PSMD4	P55036	RAD23A	Homo sapiens	P54725	NMR	12970176
Intra	PSMD4	P55036	PSMD6	Homo sapiens	Q15008	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMD6	Homo sapiens	Q15008	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD6	Homo sapiens	Q15008	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMC2	Homo sapiens	P35998	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMC2	Homo sapiens	P35998	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMC2	Homo sapiens	P35998	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMC3	Homo sapiens	P17980	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMC3	Homo sapiens	P17980	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD12	Homo sapiens	O00232	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMD12	Homo sapiens	O00232	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMD12	Homo sapiens	O00232	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PSMD4	P55036	PSMA2	Homo sapiens	P25787	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMA2	Homo sapiens	P25787	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	UBQLN1	Homo sapiens	Q9UMX0	Pull Down	20059542
Intra	PSMD4	P55036	UBQLN1	Homo sapiens	Q9UMX0	Pull Down	17082820
Intra	PSMD4	P55036	PSMC4	Homo sapiens	P43686	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	PSMC4	Homo sapiens	P43686	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	PSMC4	Homo sapiens	P43686	Anti Tag CoIP	35271311
Intra	PSMD4	P55036	UBE3A	Homo sapiens	Q05086	Anti Tag CoIP	33961781
Intra	PSMD4	P55036	UBE3A	Homo sapiens	Q05086	Y2H Pooling	21653829
Intra	PSMD4	P55036	UBE3A	Homo sapiens	Q05086	GMS	29426014
Intra	PSMD4	P55036	UBE3A	Homo sapiens	Q05086	Anti Tag CoIP	21653829
Intra	PSMD4	P55036	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	16990800
Intra	PSMD4	P55036	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	33961781
Cross	PSMD4	P55036	Rbck1	Rattus norvegicus	Q62921	Anti Tag CoIP	19796170
Cross	PSMD4	P55036	Rbck1	Rattus norvegicus	Q62921	Anti Bait CoIP	19796170

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11325	PSMD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMD4	VGNC	VGNC:107608
Rattus norvegicus	PSMD4	RGD	RGD:621109
Bos taurus	PSMD4	VGNC	VGNC:33468
Mus musculus	PSMD4	MGD	MGI:1201670
Canis familiaris	PSMD4	VGNC	VGNC:45113
Macaca mulatta	PSMD4	VGNC	VGNC:100049

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