2. Gene
  3. DDX46 - DEAD-box helicase 46 Gene

DDX46 - DEAD-box helicase 46 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Prp5; PRPF5

Gene ID: 9879 | Gene type: protein coding

About DDX46

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,758,779-134,831,121 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 38 paralogues. Ubiquitous expression in appendix (RPKM 11.5), lymph node (RPKM 11.4) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

DDX46 Products(2)

mRNA Protein Name
NM_001300860.2 NP_001287789.1 probable ATP-dependent RNA helicase DDX46 isoform 1
NM_014829.4 NP_055644.2 probable ATP-dependent RNA helicase DDX46 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Biological Process GO Annotation Evidence Reference Source
involved in U2-type prespliceosome assembly IDA
IDA: Inferred from direct assay
36797247 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
32494006 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX46 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (396 - 568)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (639 - 714)

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  • 1031 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03652 DDX46 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DDX46 VGNC VGNC:39859
Mus musculus DDX46 MGD MGI:1920895
Felis catus DDX46 VGNC VGNC:102184
Macaca mulatta DDX46 VGNC VGNC:71663
Bos taurus DDX46 VGNC VGNC:27969
Rattus norvegicus DDX46 RGD RGD:708480