SRPK2 - SRSF protein kinase 2 Gene

Homo sapiens

Also known as SFRSK2

Gene ID: 6733 | Gene type: protein coding

About SRPK2

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:105,114,740-105,399,357 (from NCBI)

This gene has 15 transcripts (splice variants), 236 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nucleic acid metabolic process; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

SRPK2 Products(12)

mRNA	Protein	Name
NM_001278273.2	NP_001265202.1	SRSF protein kinase 2 isoform b precursor
NM_001350738.2	NP_001337667.1	SRSF protein kinase 2 isoform b
NM_001350739.2	NP_001337668.1	SRSF protein kinase 2 isoform c
NM_001350740.2	NP_001337669.1	SRSF protein kinase 2 isoform d
NM_001350741.2	NP_001337670.1	SRSF protein kinase 2 isoform e
NM_001350742.2	NP_001337671.1	SRSF protein kinase 2 isoform f
NM_001350743.2	NP_001337672.1	SRSF protein kinase 2 isoform g
NM_001350744.2	NP_001337673.1	SRSF protein kinase 2 isoform g
NM_001350745.2	NP_001337674.1	SRSF protein kinase 2 isoform h
NM_001350746.2	NP_001337675.1	SRSF protein kinase 2 isoform i
NM_182691.3	NP_872633.1	SRSF protein kinase 2 isoform b precursor
NM_182692.3	NP_872634.1	SRSF protein kinase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9472028	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9472028	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9472028	GOA
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	26167880	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in R-loop processing	IDA IDA: Inferred from direct assay	28076779	GOA
involved in RNA splicing	IDA IDA: Inferred from direct assay	9472028	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9472028	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	12417631	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	26167880	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18559500	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	20498328	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9472028	GOA
involved in spliceosomal complex assembly	IDA IDA: Inferred from direct assay	9472028	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	28076779	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9472028	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	28076779	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	28076779	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9472028	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPK2 Protein Structure

Pkinase

0
200
400
600
688 a.a.

Protein Preferred Names

Protein Names

SRSF protein kinase 2

SFRS protein kinase 2

SRPK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRPK2	P78362	rnps1	Homo sapiens	D3DU92	Validated Y2H	25416956
Intra	SRPK2	P78362	rnps1	Homo sapiens	D3DU92	Y2H Prey Pooling	25416956
Intra	SRPK2	P78362	U2AF1	Homo sapiens	Q01081-2	Validated Y2H	25416956
Intra	SRPK2	P78362	LUZP4	Homo sapiens	Q9P127	Validated Y2H	25416956
Intra	SRPK2	P78362	RIMS1	Homo sapiens	Q86UR5	Anti Bait CoIP	37207277
Intra	SRPK2	P78362	SREK1	Homo sapiens	Q8WXA9	Pull Down	32707033
Intra	SRPK2	P78362	SREK1	Homo sapiens	Q8WXA9	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	Y2H	22365833
Intra	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	Pull Down	32707033
Intra	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	TAP	23602568
Intra	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	Pull Down	32707033
Intra	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	BiFC	23602568
Intra	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	TAP	23602568
Intra	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6-2	Validated Y2H	32296183
Intra	SRPK2	P78362	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368-2	Y2H Array	32296183
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368-2	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	HCN1	Homo sapiens	O60741	Anti Bait CoIP	37207277
Intra	SRPK2	P78362	SRSF11	Homo sapiens	Q05519-2	Validated Y2H	32296183
Intra	SRPK2	P78362	SRSF11	Homo sapiens	Q05519-2	Y2H Array	32296183
Intra	SRPK2	P78362	SRSF11	Homo sapiens	Q05519-2	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	ZSCAN12	Homo sapiens	O43309	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	ZSCAN12	Homo sapiens	O43309	Y2H Array	32296183
Intra	SRPK2	P78362	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	SRPK2	P78362	PRR20D	Homo sapiens	P86480	Validated Y2H	32296183
Intra	SRPK2	P78362	SNRNP27	Homo sapiens	Q8WVK2	Y2H	22365833
Intra	SRPK2	P78362	DDX46	Homo sapiens	Q7L014	Pull Down	32707033
Intra	SRPK2	P78362	DDX46	Homo sapiens	Q7L014	TAP	23602568
Intra	SRPK2	P78362	DDX46	Homo sapiens	Q7L014	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	ARL6IP4	Homo sapiens	Q66PJ3	Pull Down	32707033
Intra	SRPK2	P78362	ARL6IP4	Homo sapiens	Q66PJ3	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	TRA2A	Homo sapiens	Q13595	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	TRA2A	Homo sapiens	Q13595	Pull Down	32707033
Intra	SRPK2	P78362	NOM1	Homo sapiens	Q5C9Z4	Y2H Array	32296183
Intra	SRPK2	P78362	NOM1	Homo sapiens	Q5C9Z4	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	NOM1	Homo sapiens	Q5C9Z4	Validated Y2H	32296183
Intra	SRPK2	P78362	ARGLU1	Homo sapiens	Q9NWB6	Y2H	22365833
Intra	SRPK2	P78362	ARGLU1	Homo sapiens	Q9NWB6	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	TAP	23602568
Intra	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	BiFC	23602568
Intra	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	Pull Down	32707033
Intra	SRPK2	P78362	CHTOP	Homo sapiens	Q9Y3Y2	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	CHTOP	Homo sapiens	Q9Y3Y2	Pull Down	32707033
Intra	SRPK2	P78362	LUC7L2	Homo sapiens	Q9Y383	Pull Down	32707033
Intra	SRPK2	P78362	LUC7L2	Homo sapiens	Q9Y383	TAP	23602568
Intra	SRPK2	P78362	SRSF10	Homo sapiens	O75494	Pull Down	32707033
Intra	SRPK2	P78362	SRSF10	Homo sapiens	O75494	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	DDX21	Homo sapiens	Q9NR30	TAP	23602568
Intra	SRPK2	P78362	HNRNPC	Homo sapiens	P07910	TAP	23602568
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Validated Y2H	25416956
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Pull Down	32707033
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Y2H Prey Pooling	25416956
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Y2H Array	25416956
Intra	SRPK2	P78362	RBM39	Homo sapiens	Q14498	TAP	23602568
Intra	SRPK2	P78362	RNPS1	Homo sapiens	Q15287	Y2H	22365833
Intra	SRPK2	P78362	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
Intra	SRPK2	P78362	RNPS1	Homo sapiens	Q15287	Pull Down	32707033
Intra	SRPK2	P78362	TCOF1	Homo sapiens	Q13428	Pull Down	32707033
Intra	SRPK2	P78362	ACIN1	Homo sapiens	Q9UKV3	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	ACIN1	Homo sapiens	Q9UKV3	TAP	23602568
Intra	SRPK2	P78362	ACIN1	Homo sapiens	Q9UKV3	Y2H	22365833
Intra	SRPK2	P78362	SRSF7	Homo sapiens	Q16629	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	SRSF7	Homo sapiens	Q16629	TAP	23602568
Intra	SRPK2	P78362	RBM8A	Homo sapiens	Q9Y5S9	TAP	23602568
Intra	SRPK2	P78362	LUC7L	Homo sapiens	Q9NQ29	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	LUC7L	Homo sapiens	Q9NQ29	Pull Down	32707033
Intra	SRPK2	P78362	LUC7L	Homo sapiens	Q9NQ29	TAP	23602568
Intra	SRPK2	P78362	SRSF12	Homo sapiens	Q8WXF0	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	SRSF12	Homo sapiens	Q8WXF0	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	NSRP1	Homo sapiens	Q9H0G5	Anti Tag CoIP	35271311
Intra	SRPK2	P78362	NSRP1	Homo sapiens	Q9H0G5	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	Anti Tag CoIP	23602568
Intra	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	TAP	23602568
Intra	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	Y2H	22365833
Intra	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	Y2H Array	25416956
Intra	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6	TAP	23602568
Intra	SRPK2	P78362	ZRSR2	Homo sapiens	Q15696	Validated Y2H	32296183
Intra	SRPK2	P78362	ZRSR2	Homo sapiens	Q15696	Y2H Array	25416956
Intra	SRPK2	P78362	ZRSR2	Homo sapiens	Q15696	Validated Y2H	25416956
Intra	SRPK2	P78362	RSRC1	Homo sapiens	Q96IZ7	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Y2H Array	25416956
Intra	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Pull Down	32707033
Intra	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Y2H	22365833
Intra	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	SRPK2	P78362	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	SRPK2	P78362	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	SRPK2	P78362	SRSF5	Homo sapiens	Q13243	Pull Down	32707033
Intra	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
Intra	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Pull Down	32707033
Intra	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	FXR2	Homo sapiens	P51116	Y2H Array	25416956
Intra	SRPK2	P78362	FXR2	Homo sapiens	P51116	Pull Down	32707033
Intra	SRPK2	P78362	HOXB6	Homo sapiens	P17509	Y2H Array	32296183
Intra	SRPK2	P78362	HOXB6	Homo sapiens	P17509	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368	TAP	23602568
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368	BiFC	23602568
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368	Pull Down	32707033
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368	Y2H Pooling	16189514
Intra	SRPK2	P78362	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	23602568
Intra	SRPK2	P78362	MMTAG2	Homo sapiens	Q9BU76	TAP	23602568
Intra	SRPK2	P78362	MMTAG2	Homo sapiens	Q9BU76	Pull Down	32707033
Intra	SRPK2	P78362	MMTAG2	Homo sapiens	Q9BU76	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	CLK3	Homo sapiens	P49761	Y2H Array	25416956
Intra	SRPK2	P78362	CLK3	Homo sapiens	P49761	Anti Tag CoIP	33961781
Intra	SRPK2	P78362	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	25416956
Intra	SRPK2	P78362	CLK3	Homo sapiens	P49761	Validated Y2H	25416956
Intra	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Validated Y2H	32296183
Intra	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	32296183
Intra	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Y2H	22365833
Intra	SRPK2	P78362	CLK2	Homo sapiens	P49760	Validated Y2H	25416956
Intra	SRPK2	P78362	ZSCAN9	Homo sapiens	O15535	Y2H Array	32296183
Intra	SRPK2	P78362	ZSCAN9	Homo sapiens	O15535	Y2H Prey Pooling	25416956
Intra	SRPK2	P78362	ZSCAN9	Homo sapiens	O15535	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	RBM23	Homo sapiens	Q86U06	Protein Kinase Assay	23602568
Intra	SRPK2	P78362	COIL	Homo sapiens	P38432	Y2H Prey Pooling	32296183
Intra	SRPK2	P78362	COIL	Homo sapiens	P38432	Y2H Array	32296183
Intra	SRPK2	P78362	RSRC2	Homo sapiens	Q7L4I2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148518	MSC-1186	Inhibitor	99.42%	Unkown
HY-113831	CLK1/2-IN-3	Inhibitor	/	Unkown
HY-RS13778	SRPK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SRPK2	MGD	MGI:1201408
Felis catus	SRPK2	VGNC	VGNC:65688
Bos taurus	SRPK2	VGNC	VGNC:35289
Canis familiaris	SRPK2	VGNC	VGNC:46811
Rattus norvegicus	SRPK2	RGD	RGD:1305107
Macaca mulatta	SRPK2	VGNC	VGNC:81764
Others	SRPK2	NCBI

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