NCAPD2 - non-SMC condensin I complex subunit D2 Gene

Homo sapiens

Also known as CNAP1; CAP-D2; MCPH21; hCAP-D2

Gene ID: 9918 | Gene type: protein coding

About NCAPD2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,494,102-6,531,955 (from NCBI)

This gene has 13 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 20.3), bone marrow (RPKM 14.5) and 24 other tissues.

Summary

Enables histone binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytosol; and nucleoplasm. Part of condensin complex. Colocalizes with cytoplasm and nuclear chromosome. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]

NCAPD2 Products(1)

mRNA	Protein	Name
NM_014865.4	NP_055680.3	condensin complex subunit 1

NCAPD2 Protein Structure

Cnd1_N

Cnd1

0
300
600
900
1200
1401 a.a.

Protein Preferred Names

Protein Names

condensin complex subunit 1

XCAP-D2 homolog

Related Diseases

Diseases

Alias

Microcephaly 21, Primary, Autosomal Recessive

MCPH21

Spastic Monoplegia

Monoplegic Infantile Cerebral Palsy	Spastic Monoplegic Cerebral Palsy
Infantile Monoplegic Cerebral Palsy	Cerebral Palsy Spastic Monoplegic
Spastic Monoplegia Cerebral Palsy

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Microcephaly 19, Primary, Autosomal Recessive

MCPH19	Primary Autosomal Recessive Microcephaly 19
Microcephaly, Type 19, Primary, Autosomal Recessive

Osteogenesis Imperfecta, Type Ix

Osteogenesis Imperfecta Type 9	Osteogenesis Imperfecta Type Ix
OI9	Oi Type Ix
Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen	Oi, Type Ix
Oi 9	Osteogenesis Imperfecta 9
Oi-Ix

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09066	NCAPD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NCAPD2	VGNC	VGNC:43639
Rattus norvegicus	NCAPD2	RGD	RGD:1562596
Macaca mulatta	NCAPD2	VGNC	VGNC:75015
Bos taurus	NCAPD2	VGNC	VGNC:31901
Mus musculus	NCAPD2	MGD	MGI:1915548
Felis catus	NCAPD2	VGNC	VGNC:82373

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