NCAPH - non-SMC condensin I complex subunit H Gene

Homo sapiens

Also known as CAPH; BRRN1; CAP-H; MCPH23

Gene ID: 23397 | Gene type: protein coding

About NCAPH

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,335,766-96,377,091 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and is associated with 2 phenotypes. Biased expression in testis (RPKM 8.6), bone marrow (RPKM 4.4) and 11 other tissues.

Summary

This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

NCAPH Products(4)

mRNA	Protein	Name
NM_001281710.2	NP_001268639.1	condensin complex subunit 2 isoform 2
NM_001281711.2	NP_001268640.1	condensin complex subunit 2 isoform 3
NM_001281712.2	NP_001268641.1	condensin complex subunit 2 isoform 4
NM_015341.5	NP_056156.2	condensin complex subunit 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17268547	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic chromosome condensation	IDA IDA: Inferred from direct assay	11136719	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	27737959	GOA
involved in positive regulation of chromosome condensation	IDA IDA: Inferred from direct assay	17268547	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of condensin complex	IDA IDA: Inferred from direct assay	11136719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAPH Protein Structure

Cnd2

0
200
400
600
741 a.a.

Protein Preferred Names

Protein Names

condensin complex subunit 2

barren homolog 1

NCAPH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NCAPH	Q15003	NCAPD2	Homo sapiens	Q15021	Anti Tag CoIP	35271311
Intra	NCAPH	Q15003	NCAPD2	Homo sapiens	Q15021	Pull Down	17268547
Intra	NCAPH	Q15003	NCAPD2	Homo sapiens	Q15021	Anti Bait CoIP	17268547
Intra	NCAPH	Q15003	NCAPD2	Homo sapiens	Q15021	Anti Tag CoIP	26496610
Intra	NCAPH	Q15003	SMC2	Homo sapiens	O95347	Anti Tag CoIP	35271311
Intra	NCAPH	Q15003	SMC2	Homo sapiens	O95347	Pull Down	17268547
Intra	NCAPH	Q15003	SMC2	Homo sapiens	O95347	Anti Tag CoIP	21633354
Intra	NCAPH	Q15003	SMC2	Homo sapiens	O95347	Anti Tag CoIP	26496610
Intra	NCAPH	Q15003	SMC2	Homo sapiens	O95347	Anti Bait CoIP	17268547
Intra	NCAPH	Q15003	SMC4	Homo sapiens	Q9NTJ3	Pull Down	17268547
Intra	NCAPH	Q15003	SMC4	Homo sapiens	Q9NTJ3	Anti Tag CoIP	35271311
Intra	NCAPH	Q15003	SMC4	Homo sapiens	Q9NTJ3	Anti Tag CoIP	26496610
Intra	NCAPH	Q15003	SMC4	Homo sapiens	Q9NTJ3	Anti Bait CoIP	17268547
Intra	NCAPH	Q15003	NCAPG	Homo sapiens	Q9BPX3	Anti Bait CoIP	17268547
Intra	NCAPH	Q15003	NCAPG	Homo sapiens	Q9BPX3	Anti Tag CoIP	26496610
Intra	NCAPH	Q15003	NCAPG	Homo sapiens	Q9BPX3	Anti Tag CoIP	35271311
Intra	NCAPH	Q15003	NCAPG	Homo sapiens	Q9BPX3	Pull Down	17268547

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly 23, Primary, Autosomal Recessive

MCPH23

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09070	NCAPH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09071	NCAPH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NCAPH	VGNC	VGNC:63734
Rattus norvegicus	NCAPH	RGD	RGD:1596799
Canis familiaris	NCAPH	VGNC	VGNC:43643
Bos taurus	NCAPH	VGNC	VGNC:31905
Mus musculus	NCAPH	MGD	MGI:2444777
Macaca mulatta	NCAPH	VGNC	VGNC:108147

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