SLC23A1 - solute carrier family 23 member 1 Gene

Homo sapiens

Also known as SVCT1; YSPL3; SLC23A2

Gene ID: 9963 | Gene type: protein coding

About SLC23A1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,367,196-139,385,676 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 24.6), kidney (RPKM 21.3) and 4 other tissues.

Summary

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

SLC23A1 Products(2)

mRNA	Protein	Name
NM_005847.5	NP_005838.3	solute carrier family 23 member 1 isoform a
NM_152685.4	NP_689898.2	solute carrier family 23 member 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables L-ascorbate:sodium symporter activity	IDA IDA: Inferred from direct assay	10556483	GOA
enables L-ascorbate:sodium symporter activity	IDA IDA: Inferred from direct assay	10556483	GOA
enables L-ascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	10631088	GOA
enables dehydroascorbic acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18247577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18094143	GOA
enables urate transmembrane transporter activity	IDA IDA: Inferred from direct assay	36749388	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in L-ascorbic acid transmembrane transport	IDA IDA: Inferred from direct assay	10556483	GOA
involved in L-ascorbic acid transmembrane transport	IDA IDA: Inferred from direct assay	10556483	GOA
involved in dehydroascorbic acid transport	IMP IMP: Inferred from mutant phenotype	18247577	GOA
involved in response to toxic substance	IDA IDA: Inferred from direct assay	17575980	GOA
involved in sodium ion transport	IDA IDA: Inferred from direct assay	18094143	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15993839	GOA
located in intracellular organelle	IDA IDA: Inferred from direct assay	15993839	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10631088	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 23 member 1

Na(+)/L-ascorbic acid transporter 1

SLC23A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC23A1	Q9UHI7	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	AHCYL1	Homo sapiens	O43865	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	AHCYL1	Homo sapiens	O43865	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SLC23A1	Q9UHI7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Aggressive Periodontitis

Juvenile Periodontitis	Periodontitis, Juvenile
Prepubertal Periodontitis

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2	FHL2
Hplh2	Hlh2
Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To	Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

Osmotic Diarrhea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13081	SLC23A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC23A1	VGNC	VGNC:65247
Rattus norvegicus	SLC23A1	RGD	RGD:619875
Canis familiaris	SLC23A1	VGNC	VGNC:46282
Macaca mulatta	SLC23A1	VGNC	VGNC:77423
Bos taurus	SLC23A1	VGNC	VGNC:34733
Mus musculus	SLC23A1	MGD	MGI:1341903

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